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\n\u300c\u80cc\u666f\uff11\u300d\u73fe\u5728\u3001\u98df\u751f\u6d3b\u306e\u6b27\u7c73\u5316\u3084\u6162\u6027\u7684\u306a\u904b\u52d5\u4e0d\u8db3\u306a\u3069\u306b\u3088\u308a\u3001\u6211\u304c\u56fd\u306b\u304a\u3051\u308b\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u60a3\u8005\u6570\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3002\u96e3\u30c7\u30ad\u306e\u6442\u53d6\u306b\u3088\u308b\u98df\u5f8c\u8840\u4e2d\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u6291\u5236\u6a5f\u80fd\u306b\u306f\u5065\u5eb7\u306e\u7dad\u6301\u30fb\u5897\u9032\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\uff08\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff09\u3092\u5b9f\u65bd\u3057\u305f\u3002
\n\u300c\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u300d\u96e3\u30c7\u30ad\u306e\u98df\u5f8c\u8840\u4e2d\u8102\u80aa\u5024\u306e\u4e0a\u6607\u6291\u5236\u4f5c\u7528\u306b\u3064\u3044\u3066\u3001\u5bfe\u7167\u7fa4\u3092\u7528\u3044\u3066\u76f2\u691c\u5316\u3055\u308c\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u306b\u3088\u3063\u3066\u691c\u8a3c\u3055\u308c\u3066\u3044\u308b\u539f\u8457\u8ad6\u6587\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\uff08\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff09\u3092\u5b9f\u65bd\u3057\u305f\u3002
\n\u300c\u8abf\u67fb\u65b9\u6cd5\u300dPuBMed\u3001Cochrane Library\u3001\u533b\u4e2d\u8a8cWeb\u3001CiNii Articles\u306e\u96fb\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u4f7f\u7528\u3057\u3001\u598a\u7523\u5a66\uff08\u598a\u5a20\u3092\u8a08\u753b\u3057\u3066\u3044\u308b\u8005\u3092\u542b\u3080\u3002\uff09\u53ca\u3073\u6388\u4e73\u5a66\u3092\u9664\u304f\u3001\u7a7a\u8179\u6642\u8840\u4e2d\u4e2d\u6027\u8102\u80aa\u5024\u304c\uff12\uff10\uff10\uff4d\uff47\/\uff44L\u672a\u6e80\u306e\u6210\u4eba\uff08\u7a7a\u8179\u6642\u8840\u4e2d\u4e2d\u6027\u8102\u80aa\u5024\uff11\uff15\uff10\uff4d\uff47\/\uff44L\u672a\u6e80\u306e\u5065\u5e38\u6210\u4eba\u304a\u3088\u3073\u6a5f\u80fd\u6027\u8868\u793a\u98df\u54c1\u5236\u5ea6\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u88ab\u9a13\u8005\u3068\u3057\u3066\u8a55\u4fa1\u5bfe\u8c61\u306b\u542b\u307e\u308c\u308b\u3053\u3068\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u7a7a\u8179\u6642\u8840\u4e2d\u8102\u80aa\u5024\u304c\u3084\u3084\u9ad8\u3081\uff08\uff11\uff15\uff10\uff5e\uff11\uff19\uff19\uff4d\uff47\/\uff44L\uff09\u306e\u8efd\u75c7\u8005\uff09\u3092\u5bfe\u8c61\u3068\u3057\u3001\u98df\u4e8b\u3068\u96e3\u30c7\u30ad\u3092\u6442\u3063\u305f\u5834\u5408\u3067\u3001\u98df\u4e8b\u3068\u30d7\u30e9\u30bb\u30dc\uff08\u96e3\u30c7\u30ad\u3092\u542b\u307e\u306a\u3044\u5bfe\u7167\u98df\u54c1\uff09\u3092\u6442\u3063\u305f\u5834\u5408\u3068\u6bd4\u3079\u98df\u5f8c\u306e\u8840\u4e2d\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u304c\u6291\u5236\u3055\u308c\u308b\u304b\u3001\u306b\u3064\u3044\u3066\u8abf\u67fb\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u3092\u53ce\u96c6\u3057\u305f\u3002\u5404RCT\u8ad6\u6587\u306e\u8cea\u306e\u8a55\u4fa1\u3092\u884c\u3044\u3001\u96e3\u30c7\u30ad\u306e\u6442\u53d6\u7fa4\u3068\u5bfe\u7167\u7fa4\u306e\u5dee\u306e\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u305f\u3002\u7d71\u5408\u306e\u624b\u6cd5\u306f\u3001Random effect model\u3067\u3042\u308bDerSimonian-Laired\u6cd5\u3092\u7528\u3044\u305f\u3002
\n\u306a\u304a\u3001\u539f\u30c7\u30fc\u30bf\u3092\u78ba\u8a8d\u3067\u304d\u305f\u8ad6\u6587\uff11\u5831\u306b\u3064\u3044\u3066\u306f\u3001\u7a7a\u8179\u6642\u8840\u4e2d\u4e2d\u6027\u8102\u80aa\u5024\u304c\u3084\u3084\u9ad8\u3081\u306e\u8efd\u75c7\u8005\u3092\u9664\u3044\u305f\u5065\u5e38\u6210\u4eba\u306e\u307f\u3067\u306e\u8ffd\u52a0\u7684\u89e3\u6790\u3092\u884c\u3063\u305f\u3002
\n\u300c\u4e3b\u306a\u7d50\u679c\uff11\u300d\uff19\u5831\u306e\u8ad6\u6587\u304c\u62bd\u51fa\u3055\u308c\u3001\u7d71\u8a08\u89e3\u6790\u306e\u7d50\u679c\u3001\u30d7\u30e9\u30bb\u30dc\u6442\u53d6\u3068\u6bd4\u8f03\u3057\u3066\u96e3\u30c7\u30ad\u6442\u53d6\u304c\u98df\u5f8c\u306e\u8840\u4e2d\u4e2d\u6027\u8102\u80aa\u5024\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u53c8\u3001\u7a7a\u8179\u6642\u8840\u4e2d\u4e2d\u6027\u8102\u80aa\u5024\u304c\u3084\u3084\u9ad8\u3081\u306e\u8efd\u75c7\u8005\u3092\u9664\u3044\u305f\u5065\u5e38\u6210\u4eba\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u305f\u89e3\u6790\u7d50\u679c\u306b\u304a\u3044\u3066\u3082\u3001\u540c\u69d8\u306e\u7d50\u679c\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002
\n\u300c\u79d1\u5b66\u7684\u6839\u62e0\u306e\u8cea\uff11\u300d\u96e3\u30c7\u30ad\u306e\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u306a\u304b\u3063\u305f\u672a\u767a\u8868\u30c7\u30fc\u30bf\u304c\u5b58\u5728\u3059\u308b\u516c\u8868\u30d0\u30a4\u30a2\u30b9\u306e\u53ef\u80fd\u6027\u306f\u5426\u5b9a\u3067\u304d\u306a\u3044\u3082\u306e\u306e\u3001Fale-Safe N\u3092\u8003\u616e\u3059\u308b\u3068\u516c\u8868\u30d0\u30a4\u30a2\u30b9\u306e\u5f71\u97ff\u306f\u5c0f\u3055\u3044\u3068\u5224\u65ad\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u672c\u30ec\u30d3\u30e5\u30fc\u306e\u7d50\u679c\u306f\u3001\u96e3\u30c7\u30ad\u306e\u98df\u5f8c\u306e\u8840\u4e2d\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u3092\u304a\u3060\u3084\u304b\u306b\u3059\u308b\u6a5f\u80fd\u3092\u652f\u6301\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002
\n\u300c\u6a19\u984c\uff12\u300d\u96e3\u6d88\u5316\u6027\u30c7\u30ad\u30b9\u30c8\u30ea\u30f3\u306e\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3092\u304a\u3060\u3084\u304b\u306b\u3059\u308b\u6a5f\u80fd
\n\u300c\u76ee\u7684\uff12\u300d\u5065\u5e38\u6210\u4eba\u304c\u96e3\u6d88\u5316\u6027\u30c7\u30ad\u30b9\u30c8\u30ea\u30f3\uff08\u4ee5\u5f8c\u3001\u96e3\u30c7\u30ad\u3068\u547c\u79f0\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u6291\u5236\u4f5c\u7528\u304c\u898b\u3089\u308c\u308b\u304b\u3092\u78ba\u8a8d\u3057\u305f\u3002
\n\u300c\u80cc\u666f\uff12\u300d\u73fe\u5728\u3001\u98df\u751f\u6d3b\u306e\u6b27\u7c73\u5316\u3084\u6162\u6027\u7684\u306a\u904b\u52d5\u4e0d\u8db3\u306a\u3069\u306b\u3088\u308a\u3001\u6211\u304c\u56fd\u306b\u304a\u3051\u308b\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u60a3\u8005\u6570\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3002\u96e3\u30c7\u30ad\u306e\u6442\u53d6\u306b\u3088\u308b\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u6291\u5236\u6a5f\u80fd\u306b\u306f\u5065\u5eb7\u306e\u7dad\u6301\u30fb\u5897\u9032\u304c\u671f\u5f85\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\uff08\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff09\u3092\u5b9f\u65bd\u3057\u305f\u3002
\n\u300c\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff12\u300d\u96e3\u30c7\u30ad\u306e\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u6291\u5236\u4f5c\u7528\u306b\u3064\u3044\u3066\u3001\u5bfe\u7167\u7fa4\u3092\u7528\u3044\u3066\u76f2\u691c\u5316\u3055\u308c\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u306b\u3088\u3063\u3066\u691c\u8a3c\u3055\u308c\u3066\u3044\u308b\u539f\u8457\u8ad6\u6587\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\uff08\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff09\u3092\u5b9f\u65bd\u3057\u305f\u3002
\n\u300c\u8abf\u67fb\u65b9\u6cd5\uff12\u300dPuBMed\u3001Cochrane Library\u3001\u533b\u4e2d\u8a8cWeb\u3001CiNii Articles\u306e\u96fb\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u4f7f\u7528\u3057\u3001\u598a\u7523\u5a66\uff08\u598a\u5a20\u3092\u8a08\u753b\u3057\u3066\u3044\u308b\u8005\u3092\u542b\u3080\u3002\uff09\u53ca\u3073\u6388\u4e73\u5a66\u3092\u9664\u304f\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u5024\uff11\uff12\uff16\uff4d\uff47\/\uff44L\u672a\u6e80\u306e\u5065\u5e38\u6210\u4eba\uff08\u5065\u5e38\u6210\u4eba\uff08\u7a7a\u8179\u6642\u8840\u7cd6\u5024\uff11\uff11\uff10\uff4d\uff47\/\uff44L\u672a\u6e80\uff09\u304a\u3088\u3073\u5883\u754c\u57df\u8840\u7cd6\u5024\u306e\u6210\u4eba\uff08\u7a7a\u8179\u6642\u8840\u7cd6\u5024\uff11\uff11\uff10\uff5e\uff11\uff12\uff16\uff4d\uff47\/\uff44L\uff09\uff09\u306b\u3066\u3001\u98df\u4e8b\u3068\u96e3\u30c7\u30ad\u3092\u6442\u3063\u305f\u5834\u5408\u3068\u6bd4\u3079\u3066\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u4e0a\u6607\u304c\u6291\u5236\u3055\u308c\u308b\u304b\u3001\u306b\u3064\u3044\u3066\u8abf\u67fb\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u3092\u53ce\u96c6\u3057\u305f\u3002\u5404RCT\u8ad6\u6587\u306e\u8cea\u306e\u8a55\u4fa1\u3092\u884c\u3044\u3001\u96e3\u30c7\u30ad\u306e\u6442\u53d6\u7fa4\u3068\u5bfe\u7167\u7fa4\u306e\u5dee\u306e\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u305f\u3002\u7d71\u5408\u306e\u624b\u6cd5\u306f\u3001Random effect model\u3067\u3042\u308bDerSimonian-Laired\u6cd5\u3092\u7528\u3044\u305f\u3002
\n\u306a\u304a\u3001\u5883\u754c\u57df\u8840\u7cd6\u5024\u306e\u6210\u4eba\u3092\u9664\u304f\u5065\u5e38\u6210\u4eba\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u305fRCT\u8a66\u9a13\u306b\u3064\u3044\u3066\u3082\u8ffd\u52a0\u7684\u89e3\u6790\u3092\u884c\u3063\u305f\u3002
\n\u300c\u4e3b\u306a\u7d50\u679c\uff12\u300d\uff14\uff13\u5831\u306e\u8ad6\u6587\u304c\u62bd\u51fa\u3055\u308c\u3001\u7d71\u8a08\u89e3\u6790\u306e\u7d50\u679c\u3001\u30d7\u30e9\u30bb\u30dc\u6442\u53d6\u3068\u6bd4\u8f03\u3057\u3066\u96e3\u30c7\u30ad\u306e\u6442\u53d6\u304c\u6709\u610f\u306b\u98df\u5f8c\u8840\u7cd6\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u53c8\u3001\u5883\u754c\u57df\u8840\u7cd6\u5024\u306e\u6210\u4eba\u3092\u9664\u304f\u5065\u5e38\u6210\u4eba\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u305fRCT\u8a66\u9a13\u3082\uff11\uff10\u5831\u304c\u62bd\u51fa\u3055\u308c\u3001\u540c\u69d8\u306e\u7d50\u679c\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002
\n\u300c\u79d1\u5b66\u7684\u6839\u62e0\u306e\u8cea\uff12\u300d\u96e3\u30c7\u30ad\u306e\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u305f\u306a\u304b\u3063\u305f\u672a\u767a\u8868\u30c7\u30fc\u30bf\u304c\u5b58\u5728\u3059\u308b\u516c\u8868\u30d0\u30a4\u30a2\u30b9\u306e\u53ef\u80fd\u6027\u306f\u5426\u5b9a\u3067\u304d\u306a\u3044\u3082\u306e\u306e\u3001Fale-Safe N\u3092\u8003\u616e\u3059\u308b\u3068\u516c\u8868\u30d0\u30a4\u30a2\u30b9\u306e\u5f71\u97ff\u306f\u5c0f\u3055\u3044\u3068\u5224\u65ad\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u672c\u30ec\u30d3\u30e5\u30fc\u306e\u7d50\u679c\u306f\u3001\u96e3\u30c7\u30ad\u306e\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3092\u304a\u3060\u3084\u304b\u306b\u3059\u308b\u6a5f\u80fd\u3092\u652f\u6301\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002
\n\u300c\u6a19\u984c\uff13\u300d\u96e3\u6d88\u5316\u6027\u30c7\u30ad\u30b9\u30c8\u30ea\u30f3\u306e\u304a\u8179\u306e\u8abf\u5b50\u3092\u6574\u3048\u308b\u6a5f\u80fd\uff08\u4fbf\u901a\u6539\u5584\u6a5f\u80fd\uff09
\n\u300c\u76ee\u7684\uff13\u300d\u5065\u5e38\u6210\u4eba\u3042\u308b\u3044\u306f\u4fbf\u79d8\u50be\u5411\u306e\u6210\u4eba\u304c\u96e3\u6d88\u5316\u6027\u30c7\u30ad\u30b9\u30c8\u30ea\u30f3\uff08\u4ee5\u5f8c\u3001\u96e3\u30c7\u30ad\u3068\u547c\u79f0\uff09\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u304a\u8179\u306e\u8abf\u5b50\u3092\u6574\u3048\u308b\u6a5f\u80fd\uff08\u4fbf\u901a\u6539\u5584\u6a5f\u80fd\uff09\u304c\u898b\u3089\u308c\u308b\u304b\u3092\u78ba\u8a8d\u3057\u305f\u3002
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