{"id":15364,"date":"2021-06-21T07:20:42","date_gmt":"2021-06-20T22:20:42","guid":{"rendered":"https:\/\/yakujihou-marketing.net\/database\/?p=15364"},"modified":"2021-08-13T01:47:10","modified_gmt":"2021-08-12T16:47:10","slug":"g268","status":"publish","type":"post","link":"https:\/\/yakujihou-marketing.net\/database\/g268\/","title":{"rendered":"\u30e2\u30a4\u30b9\u30c1\u30e3\u30fc\u30e1\u30f3\u30c6(G268)"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u6d88\u8cbb\u8005\u5e81URL<\/td>\nhttps:\/\/www.fld.caa.go.jp\/caaks\/cssc02\/?recordSeq=42104140730102<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u57fa\u672c\u60c5\u5831<\/h2>\n

\u5b89\u5168\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5<\/h3>\n

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1.\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na
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2.\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3
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\u6a5f\u80fd\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5<\/h3>\n

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1.\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na
\n\u3010\u6a19\u984c\u3011
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\u3010\u76ee\u7684\u3011
\n\u808c\u306e\u4e7e\u71e5\u3092\u81ea\u899a\u3059\u308b\u6210\u4eba\u5065\u5e38\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na\u306e\u7d4c\u53e3\u6442\u53d6\u306b\u3088\u308b\u808c\u306e\u4fdd\u6c34\u6027\u306e\u5411\u4e0a\u4f5c\u7528\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n

\u3010\u80cc\u666f\u3011
\n\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306f\u3001N-\u30a2\u30bb\u30c1\u30eb\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u3068\u30b0\u30eb\u30af\u30ed\u30f3\u9178\u3068\u304c\u4ea4\u4e92\u306b\u7d50\u5408\u3057\u305f\u7e70\u308a\u8fd4\u3057\u69cb\u9020\u3092\u6301\u3064\u9ad8\u5206\u5b50\u591a\u7cd6\u3067\u3042\u308a\u3001\u30e0\u30b3\u591a\u7cd6\u985e\u306b\u5206\u985e\u3055\u308c\u308b\u3002\u3053\u306e\u7269\u8cea\u306f\u3001\u30a6\u30b7\u306e\u773c\u306e\u785d\u5b50\u4f53\u306e\u6210\u5206\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305f\u304c\u3001\u76ae\u819a\u3001\u8171\u3001\u7b4b\u8089\u3001\u8edf\u9aa8\u3001\u8133\u3001\u8840\u7ba1\u7b49\u3001\u810a\u690e\u52d5\u7269\u306e\u3042\u3089\u3086\u308b\u90e8\u4f4d\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002
\n\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306f\u751f\u4f53\u5185\u306b\u304a\u3044\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5f37\u3044\u89aa\u548c\u6027\u3092\u3082\u3063\u3066\u7d50\u5408\u3059\u308b\u305f\u3081\u3001\u7d30\u80de\u9593\u9699\u306b\u5b58\u5728\u3057\u3066\u7d30\u80de\u5916\u6db2\u306e\u4fdd\u6301\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3002\u7279\u306b\u3001\u76ae\u819a\u306b\u304a\u3044\u3066\u306f\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u304c\u5931\u308f\u308c\u308b\u3068\u7d30\u80de\u5916\u6db2\u3092\u3068\u3069\u3081\u308b\u80fd\u529b\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001\u6c34\u5206\u91cf\u306e\u6e1b\u5c11\u3084\u7d30\u80de\u306e\u65b0\u9673\u4ee3\u8b1d\u304c\u4f4e\u4e0b\u3057\u76ae\u819a\u306e\u67d4\u8edf\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3002
\n\u3064\u307e\u308a\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na\u306b\u306f\u3001\u76ae\u819a\u306e\u4e7e\u71e5\u3092\u6539\u5584\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u304c\u3001\u5065\u5e38\u8005\u306b\u7d5e\u3063\u3066\u9577\u671f\u9593\u6442\u53d6\u3057\u305f\u969b\u306e\u4f5c\u7528\u306b\u95a2\u3057\u3066\u8a55\u4fa1\u3057\u305f\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u3002\u305d\u3053\u3067\u6211\u3005\u306f\u3001\u5065\u5e38\u8005\u3092\u5bfe\u8c61\u306b\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na\u306e\u7d99\u7d9a\u6442\u53d6\u306b\u3088\u308b\u808c\u306e\u4fdd\u6c34\u6027\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306b\u3064\u3044\u3066\u3001\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u306e\u624b\u6cd5\u3092\u7528\u3044\u305f\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/p>\n

\u3010\u30ec\u30d3\u30e5\u30fc\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306e\u7279\u6027\u3011
\n\u5916\u56fd\u8a9e\u53ca\u3073\u65e5\u672c\u8a9e\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u4f7f\u7528\u3057\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u30fb\u6e96RCT\u3092\u5bfe\u8c61\u306b\u691c\u7d22\u3092\u304a\u3053\u306a\u3063\u305f\u3002\u5bfe\u8c61\u306e\u96c6\u56e3\u306f\u3001\u808c\u306e\u4e7e\u71e5\u3092\u81ea\u899a\u3059\u308b\u5065\u5e38\u6210\u4eba\u7537\u5973\u3067\u3042\u308a\u3001\u6700\u7d42\u7684\u306b\u306f5\u5831\u306e\u6587\u732e\u3092\u63a1\u7528\u3057\u305f\u3002<\/p>\n

\u3010\u4e3b\u306a\u7d50\u679c\u3011
\n\u8a55\u4fa1\u5bfe\u8c61\u306e5\u5831\u3092\u8a55\u4fa1\u3057\u305f\u7d50\u679c\u30015\u5831\u4e2d4\u5831\u3067\u808c\u6c34\u5206\u91cf\u306e\u5411\u4e0a\u306b\u5bfe\u3057\u3066\u80af\u5b9a\u7684\u306a\u7d50\u679c\u3067\u3042\u308a\u3001\u305d\u306e\u969b\u306e\u4e00\u65e5\u5f53\u305f\u308a\u306e\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na\u306e\u6442\u53d6\u91cf\u306f120mg\u3067\u3042\u3063\u305f\u3002\u5bfe\u8c61\u8005\u306f30\u4ee3\u304b\u308960\u6b73\u307e\u3067\u306e\u808c\u306e\u4e7e\u71e5\u304c\u6c17\u306b\u306a\u308b\u6210\u4eba\u5065\u5e38\u7537\u5973\u3067\u3042\u308a\u3001\u5e45\u5e83\u3044\u5e74\u4ee3\u3067\u6709\u52b9\u6027\u304c\u5f97\u3089\u308c\u3066\u3044\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001totality of evidence\u306e\u89b3\u70b9\u304b\u3089\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na\u306e\u6442\u53d6\u306f\u3001\u808c\u306e\u4e7e\u71e5\u3092\u81ea\u899a\u3059\u308b\u6210\u4eba\u5065\u5e38\u8005\u306e\u808c\u306e\u4fdd\u6c34\u6027\u306e\u5411\u4e0a\u306b\u95a2\u3057\u3066\u80af\u5b9a\u7684\u3067\u3042\u308b\u3068\u5224\u65ad\u3057\u305f\u3002
\n\u672c\u54c1\u306f\u4e00\u65e5\u5f53\u305f\u308a\u306e\u6442\u53d6\u76ee\u5b89\u91cf\u4e2d\u306b\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na\u3092120mg\u542b\u3093\u3067\u304a\u308a\u3001\u808c\u306e\u4fdd\u6c34\u6027\u306e\u5411\u4e0a\u304c\u671f\u5f85\u3067\u304d\u308b\u3068\u5224\u65ad\u3057\u305f\u3002<\/p>\n

\u3010\u79d1\u5b66\u7684\u6839\u62e0\u306e\u8cea\u3011
\n\u672c\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na\u306e\u6442\u53d6\u306e\u52b9\u679c\u306b\u3064\u3044\u30665\u5831\u306eRCT\u8ad6\u6587\u3092\u8a55\u4fa1\u3057\u305f\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u306b\u95a2\u3059\u308b\u8a18\u8f09\u304c\u4e0d\u5341\u5206\u3067\u3042\u3063\u305f\u3053\u3068\u304c\u3001\u500b\u3005\u306e\u7814\u7a76\u306e\u9650\u754c\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u5168\u4f53\u306e\u30d0\u30a4\u30a2\u30b9\u30fb\u30ea\u30b9\u30af\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u4e2d\u7a0b\u5ea6\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u307e\u305f\u3001\u672c\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u306e\u9650\u754c\u3068\u3057\u3066\u3001PubMed\u3001The Cochrane Library\u3001\u533b\u4e2d\u8a8cWeb\u306e3\u3064\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u7528\u3044\u3066\u3001\u82f1\u8a9e\u3001\u548c\u6587\u306e\u4e21\u65b9\u3092\u691c\u7d22\u3057\u3066\u3044\u308b\u304c\u3001\u7db2\u7f85\u7684\u306b\u691c\u7d22\u3067\u304d\u3066\u3044\u308b\u304b\u3068\u3044\u3046\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u306f\u3042\u308b\u3002<\/p>\n

2.\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3
\n\u3010\u6a19\u984c\u3011
\n\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306e\u808c\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u7814\u7a76\u30ec\u30d3\u30e5\u30fc<\/p>\n

\u3010\u76ee\u7684\u3011
\n\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306b\u3088\u308b\u808c\u306e\u5f3e\u529b\u306e\u7dad\u6301\u306b\u5f79\u7acb\u3064\u3053\u3068\u306b\u3064\u3044\u3066\u691c\u8a3c\u3057\u305f\u3002<\/p>\n

\u3010\u80cc\u666f\u3011
\n\u76ae\u819a\u306f\u6210\u4eba\u3067\u7d041.6\u33a1\u306e\u9762\u7a4d\u306b\u304a\u3088\u3076\u4eba\u4f53\u6700\u5927\u306e\u81d3\u5668\u3067\u3042\u308b\u3002\u76ae\u819a\u306e\u4e3b\u306a\u6a5f\u80fd\u306f\u4ee5\u4e0b\u306e\uff13\u3064\u3067\u3042\u308b(1), (2)\u3002
\n\u2460 \u304b\u3089\u3060\u3092\u5916\u754c\u304b\u3089\u5b88\u308b\u6a5f\u80fd
\n\u69d8\u3005\u306a\u5916\u7684\u523a\u6fc0\u306b\u5bfe\u3057\u3001\u304b\u3089\u3060\u306e\u5185\u90e8\u7d44\u7e54\u3092\u5b88\u308b\u5f79\u5272\u3092\u679c\u305f\u3059\u3002
\n\u2461 \u4f53\u6e29\u3092\u8abf\u7bc0\u3059\u308b\u6a5f\u80fd
\n\u5916\u754c\u304b\u3089\u306e\u4f53\u6e29\u5909\u5316\u3092\u548c\u3089\u3052\u308b\u3002\u8840\u7ba1\u62e1\u5f35\u30fb\u53ce\u7e2e\u3001\u53ca\u3073\u767a\u6c57\u306e\u8abf\u7bc0\u306b\u3088\u308a\u71b1\u306e\u653e\u6563\u3092\u8abf\u7bc0\u3059\u308b\u3002\u4e00\u822c\u7684\u306b\u77e5\u3089\u308c\u308b\u76ae\u819a\u547c\u5438\u306b\u5fc5\u8981\u306a\u6a5f\u80fd\u3067\u3042\u308b\u3002
\n\u2462 \u77e5\u899a
\n\u89e6\u899a\u3001\u75db\u899a\u3001\u6e29\u899a\u3001\u51b7\u899a\u306a\u3069\u3092\u611f\u3058\u3001\u305d\u306e\u60c5\u5831\u3092\u8133\u3078\u4f1d\u3048\u308b\u3002<\/p>\n

\u76ae\u819a\u306f\u8868\u9762\u5074\u304b\u3089\u3001\u8868\u76ae\u3001\u771f\u76ae\u3001\u76ae\u4e0b\u7d44\u7e54\u306e\uff13\u3064\u306e\u7d44\u7e54\u304b\u3089\u306a\u308b\u3002\u3053\u306e\u4e2d\u3067\u3082\u3001\u7279\u306b\u3001\u771f\u76ae\u306f\u81a0\u539f\u7dda\u7dad\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u7dda\u7dad\uff09\u3068\u5f3e\u6027\u7dda\u7dad\uff08\u30a8\u30e9\u30b9\u30c1\u30f3\u7dda\u7dad\uff09\u304b\u3089\u6210\u308a\u7acb\u3061\u3001\u3053\u308c\u3089\u7dda\u7dad\u304c\u6301\u3064\u5f3e\u529b\u6027\u3092\u4f7f\u3063\u3066\u3001\u5916\u754c\u306e\u5727\u529b\u304b\u3089\u304b\u3089\u3060\u306e\u5185\u90e8\u3092\u5b88\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u65e5\u5e38\u751f\u6d3b\u306b\u304a\u3044\u3066\u3001\u7d2b\u5916\u7dda\u3001\u55ab\u7159\u3001\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u306b\u3088\u308a\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u7dda\u7dad\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u7dda\u7dad\u304c\u6e1b\u5c11\u3042\u308b\u3044\u306f\u5909\u8cea\u3059\u308b\u3068\u3001\u305d\u306e\u5f3e\u529b\u3084\u5f35\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u3002\u305d\u308c\u306b\u3088\u308a\u3001\u8868\u76ae\u304c\u50b7\u3064\u304d\u3084\u3059\u304f\u306a\u308b\u3002
\n\u8868\u76ae\u306e\u89d2\u5c64\u3082\u3001\u304b\u3089\u3060\u3092\u5916\u754c\u304b\u3089\u5b88\u308b\u6a5f\u80fd\u3092\u62c5\u3046\u3002\u89d2\u5c64\u306f\u4f53\u5185\u306e\u6c34\u5206\u3092\u4fdd\u6301\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u5916\u304b\u3089\u306e\u7570\u7269\u306e\u4fb5\u5165\u3001\u307e\u305f\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u30d0\u30ea\u30a2\u306e\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u89d2\u5c64\u306f\u3001\u76ae\u819a\u306e\u8868\u9762\u5074\u304b\u3089\u898b\u3066\u771f\u76ae\u3068\u63a5\u3059\u308b\u6700\u3082\u6df1\u3044\u90e8\u5206\u3067\u7d30\u80de\u304c\u751f\u307f\u51fa\u3055\u308c\u3001\u5f62\u3092\u5909\u3048\u306a\u304c\u3089\u4e0a\u65b9\u3078\u79fb\u52d5\u3059\u308b\u3053\u3068\u3067\u5f62\u6210\u3055\u308c\u308b\u3002\u3053\u306e\u5f62\u6210\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u771f\u76ae\u306f\u3001\u8868\u76ae\u3078\u6804\u990a\u5206\u3092\u88dc\u7d66\u3057\u3001\u3055\u3089\u306b\u8db3\u5834\u3068\u3057\u3066\u3082\u50cd\u3044\u3066\u3044\u308b(3)\u3002<\/p>\n

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\n\u7d50\u8ad6\u3068\u3057\u3066\u3001\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3092\u6442\u53d6\u3057\u305f\u5834\u5408\u3001\u808c\u306e\u5f3e\u529b\u306e\u7dad\u6301\u306b\u5f79\u7acb\u3064\u6a5f\u80fd\u304c\u3042\u308b\u3053\u3068\u306b\u95a2\u3057\u3066\u80af\u5b9a\u7684\u306a\u79d1\u5b66\u7684\u6839\u62e0\u304c\u3042\u308b\u3068\u5224\u65ad\u3057\u305f\u3002<\/p>\n

\u53c2\u8003\u6587\u732e
\n1) \u76ae\u819a\u79d1\u75be\u60a3\u30d3\u30b8\u30e5\u30a2\u30eb\u30d6\u30c3\u30af\uff1a\u5b66\u7814
\n2) \u30b7\u30f3\u30d7\u30eb\u76ae\u819a\u79d1\u5b66\u3000\u5357\u6c5f\u5802
\n3) A J Engler. et al. Matrix Elasticity Directs Stem Cell Lineage Specification, Cell. 2006,126, 677-689.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5c4a\u51fa\u756a\u53f7 G268 \u5546\u54c1\u540d \u30e2\u30a4\u30b9\u30c1\u30e3\u30fc\u30e1\u30f3\u30c6 \u5c4a\u51fa\u8005\u540d \u30d3\u30fc\u30a8\u30a4\u30c1\u30a8\u30cc\u682a\u5f0f\u4f1a\u793e \u5c4a\u51fa\u65e5 2021\/06\/21 \u5909\u66f4\u65e5 – \u64a4\u56de\u65e5 – \u8ca9\u58f2\u4e2d \u8ca9\u58f2\u4f11\u6b62\u4e2d \u98df\u54c1\u306e\u533a\u5206 \u52a0\u5de5\u98df\u54c1(\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u5f62\u72b6) […]<\/p>\n","protected":false},"author":2,"featured_media":15368,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,16,15,108],"tags":[],"class_list":{"0":"post-15364","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-skin","8":"category-moisturizing","9":"category-hyaluronic-acid","10":"category-proteoglycan"},"_links":{"self":[{"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/posts\/15364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/comments?post=15364"}],"version-history":[{"count":0,"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/posts\/15364\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/media\/15368"}],"wp:attachment":[{"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/media?parent=15364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/categories?post=15364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/yakujihou-marketing.net\/database\/wp-json\/wp\/v2\/tags?post=15364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}