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\n\u3010\u307e\u3068\u3081\u3011
\n\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u30fb\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u2161\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u306b\u3064\u3044\u3066\u306f\u540c\u539f\u6750\u6599\u3092\u7528\u3044\u305f\u8a55\u4fa1\u306b\u3066\u3001N-\u30a2\u30bb\u30c1\u30eb\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306b\u3064\u3044\u3066\u306f\u56fa\u6709\u306e\u69cb\u9020\u3092\u6709\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u4e0a\u8a18\u5b89\u5168\u6027\u8a66\u9a13\u306b\u3088\u308a\u5b89\u5168\u6027\u306f\u62c5\u4fdd\u3055\u308c\u3066\u3044\u308b\u3068\u5224\u65ad\u3057\u305f\u3002\u307e\u305f\u5404\u8ad6\u6587\u306b\u304a\u3051\u308b\u8a66\u9a13\u98df\u306e\u5f62\u614b\u3068\u672c\u54c1\u306e\u5f62\u614b\u306f\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u306e\u6d88\u5316\u30fb\u5438\u53ce\u904e\u7a0b\u306b\u5f71\u97ff\u3059\u308b\u3088\u3046\u306a\u5f62\u614b\u306e\u5dee\u306f\u898b\u5f53\u305f\u3089\u305a\u3001\u66f4\u306b\u672c\u54c1\u306b\u542b\u307e\u308c\u308b\u4ed6\u306e\u6210\u5206\u3084\u52a0\u5de5\u5de5\u7a0b\u306e\u5f71\u97ff\u306b\u3088\u308a\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u304c\u5909\u8cea\u3059\u308b\u3088\u3046\u306a\u98df\u54c1\u3067\u306f\u306a\u3044\u305f\u3081\u3001\u8a55\u4fa1\u5bfe\u8c61\u3068\u3057\u3066\u9069\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u672c\u54c1\u306e\u6442\u53d6\u306f\u5065\u5e38\u8005\u304c\u9069\u5207\u306b\u7d4c\u53e3\u6442\u53d6\u3059\u308b\u5834\u5408\u5b89\u5168\u6027\u306b\u554f\u984c\u304c\u306a\u304f\u3001\u300c\u65e2\u5b58\u60c5\u5831\u306b\u3088\u308b\u5b89\u5168\u6027\u8a66\u9a13\u306e\u8a55\u4fa1\u24632\u6b21\u60c5\u5831\u53ca\u3073\u24641\u6b21\u60c5\u5831\u300d\u306b\u3088\u308a\u672c\u54c1\u306e\u5b89\u5168\u6027\u306e\u8a55\u4fa1\u306f\u5341\u5206\u3067\u3042\u308b\u3068\u8003\u5bdf\u3059\u308b\u3053\u3068\u306b\u5bfe\u3057\u3066\u554f\u984c\u306a\u3044\u3068\u5224\u65ad\u3057\u305f\u3002<\/p>\n

\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u57fa\u672c\u60c5\u5831<\/h2>\n

\u6a5f\u80fd\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5<\/h3>\n

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\u5f53\u8a72\u88fd\u54c1\u306e\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u5c4a\u51fa\u8005\u306e\u8a55\u4fa1<\/h3>\n

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\n\u6a19\u984c\uff1a\u6700\u7d42\u88fd\u54c1\u300c\u30ce\u30a8\u30d3\u30a2\u3000\u819d\u7f8e\u65e5\u548c\uff08\u3072\u3056\u3073\u3088\u308a\uff09\u300d\u306b\u542b\u307e\u308c\u308b\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u300c\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u300d\u53ca\u3073\u300c\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u2161\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u300d\u306e\u819d\u95a2\u7bc0\u306e\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u7814\u7a76\u30ec\u30d3\u30e5\u30fc
\n\u76ee\u7684\uff1a\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u30fb\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u2161\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u819d\u95a2\u7bc0\u306e\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u6a5f\u80fd\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068
\n\u80cc\u666f\uff1a\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u53c8\u306f\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u2161\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u542b\u3080\u98df\u54c1\u306e\u819d\u95a2\u7bc0\u306e\u6a5f\u80fd\u3078\u306e\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u591a\u304f\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u4e21\u65b9\u3092\u542b\u3080\u98df\u54c1\u306b\u95a2\u3059\u308b\u5b9a\u6027\u7684\u53c8\u306f\u5b9a\u91cf\u7684\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u306e\u5831\u544a\u306f\u306a\u304b\u3063\u305f\u3002\u305d\u3053\u3067\u3001\u672c\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u7279\u306b\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u306e\u5f53\u8a722\u6210\u5206\u3092\u540c\u6642\u306b\u542b\u3080\u98df\u54c1\u306b\u3064\u3044\u3066\uff62\u5bfe\u8c61\u8005\uff1a\u5065\u5e38\u6210\u4eba\uff08\u6804\u990a\u5b66\u7684\u89b3\u70b9\u304b\u3089\u6210\u4eba\uff09\u3001\u4ecb\u5165\uff1a\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u8907\u5408\u4f5380\u309240mg(\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f316mg\u30fb\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u2161\u578b\u30b3\u30e9\u30fc\u30b2\u30f316mg)\u3092\u542b\u3080\u98df\u54c1\u306e\u7d4c\u53e3\u6442\u53d6\u3001\u6bd4\u8f03\uff1a\u30d7\u30e9\u30bb\u30dc\u98df\u54c1\u306e\u7d4c\u53e3\u6442\u53d6\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a\u819d\u95a2\u7bc0\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u3001\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\uff63\u3092\u8a2d\u5b9a\u3057\u3001\u305d\u306e\u6a5f\u80fd\u6027\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002
\n\u30ec\u30d3\u30e5\u30fc\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306e\u7279\u6027\uff1a\u691c\u7d22\u65e5\u3067\u3042\u308b2018\u5e7412\u670810\u65e5\u4ee5\u524d\u306b\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u516c\u958b\u3055\u308c\u305f\u56fd\u5185\u5916\u306e\u5065\u5eb7\u306a\u6210\u4eba\u7537\u5973\u3092\u5bfe\u8c61\u306b\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u691c\u7d22\u3057\u3001\u75be\u75c5\u306b\u7f79\u60a3\u3057\u3066\u3044\u306a\u3044\u5065\u5e38\u8005(\u65e5\u672c\u4eba60\u540d)\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8ad6\u65871\u5831\u304c\u5f97\u3089\u308c\u305f\u3002\u5f53\u8a72\u6587\u732e\u306b\u304a\u3051\u308b\u5bfe\u8c61\u8005\u306f\u75be\u75c5\u306b\u7f79\u60a3\u3057\u3066\u3044\u306a\u3044\u307e\u3067\u3082KL\u5206\u985e\u30b0\u30ec\u30fc\u30c9\u3068\u3057\u3066\u2161\u4ee5\u4e0b\u306e\u65b9\u306b\u3066\u8a66\u9a13\u304c\u6210\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u6587\u732e\u4e2d\u306b\u300c\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u3067\u306f\u306a\u3044\u5065\u5e38\u8005(KL\u5206\u985e\u30b0\u30ec\u30fc\u30c9\u2160\u4ee5\u4e0b)\u300d\u3068\u5065\u5e38\u8005\u3092\u5b9a\u7fa9\u3065\u3051\u3055\u308c\u3001\u660e\u8a18\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u6a5f\u80fd\u6027\u8868\u793a\u5236\u5ea6\u306e\u5bfe\u8c61\u8005\u3068\u306a\u308a\u3046\u308b\u8981\u4ef6\u3092\u8e0f\u307e\u3048\u3001\u672c\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u306b\u304a\u3044\u3066\u306fKL\u5206\u985e\u30b0\u30ec\u30fc\u30c9\u2160\u4ee5\u4e0b\u306e\u65b9\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3057\u305f\u3002\u307e\u305f\u3001\u5f53\u8a72\u6587\u732e\u306b\u304b\u304b\u308b\u7814\u7a76\u8cbb\u7528\u306f\u539f\u6599\u4f9b\u7d66\u8005\u304c\u63d0\u4f9b\u3057\u3001\u8ad6\u6587\u306e\u8457\u8005\u306b\u305d\u306e\u95a2\u4fc2\u8005\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u304c\u3001\u8a66\u9a13\u306f\u7b2c\u4e09\u8005\u6a5f\u95a2\u3067\u9069\u5207\u306b\u5b9f\u65bd\u3055\u308c\u3066\u3044\u305f\u3002
\n\u4e3b\u306a\u7d50\u679c\uff1a \u5b66\u8853\u7684\u306b\u78ba\u7acb\u3055\u308c\u305f\u819d\u306b\u95a2\u3059\u308b4\u3064\u306e\u8a55\u4fa1\uff08\u533b\u5e2b\u53c8\u306f\u30a2\u30f3\u30b1\u30fc\u30c8\u306b\u3088\u308b\u8a55\u4fa1(JOA\u3001JKOM\u3001KSS\u3001VAS)\uff09\u304c\u884c\u308f\u308c\u3001\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f316mg\/\u65e5\u3001\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u2161\u578b\u30b3\u30e9\u30fc\u30b2\u30f316 mg\/\u65e5\u3092\u6442\u53d6\u3057\u305f\u7fa4\u304c\u30d7\u30e9\u30bb\u30dc\u98df\u54c1\u3092\u6442\u53d6\u3057\u305f\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u3067\u3042\u308bJOA(\u79fb\u52d5\u80fd\u529b\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u305f\u8a66\u9a13\u30674\u9805\u76ee\u4e2d3\u9805\u76ee\uff08\u6b69\u884c\u80fd\u529b\u3001\u968e\u6bb5\u6607\u964d\u80fd\u529b\u3001\u53ef\u52d5\u57df\uff09\u304c\u819d\u306e\u66f2\u3052\u4f38\u3070\u3057\u3092\u4f34\u3046\u8a55\u4fa1)\u306e\u5408\u8a08\u70b9\u3067\u6539\u5584\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u526f\u6b21\u30a2\u30a6\u30c8\u30ab\u30e0\u3067\u3042\u308bKSS\u306b\u304a\u3044\u3066\u3082\u300c\u73fe\u5728\u306e\u6e80\u8db3\u5ea6\u300d\u306b\u95a2\u3059\u308b\u9805\u76ee\u3067\u6539\u5584\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002
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\n\u30ec\u30d3\u30e5\u30fc\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306e\u7279\u6027\uff1aNPO\u6cd5\u4eba\u65e5\u672c\u6297\u52a0\u9f62\u5354\u4f1a\u306b\u6240\u5c5e\u3059\u308b\u5c02\u9580\u77e5\u8b58\u3092\u6709\u3059\u308b\u533b\u5e2b\u82e5\u3057\u304f\u306f\u5b66\u8b58\u7d4c\u9a13\u8005\u306b\u3088\u308a\u691c\u7d22\u65e5(2018\u5e749\u670828\u65e5)\u4ee5\u524d\u306b\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u516c\u958b\u3055\u308c\u305f\u56fd\u5185\u5916\u306e\u5065\u5eb7\u306a\u6210\u4eba\u7537\u5973\u3092\u5bfe\u8c61\u306b\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u691c\u7d22\u3057\u3001\u65e5\u672c\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u6587\u732e1\u5831\u304c\u5f97\u3089\u308c\u305f\u3002\u5f53\u8a72\u6587\u732e\u306b\u304a\u3044\u3066\u30e9\u30f3\u30c0\u30e0\u5316\u3084\u89e3\u6790\u8005\u306b\u5bfe\u3059\u308b\u5272\u308a\u4ed8\u3051\u306e\u96a0\u853d\u306a\u3069\u5341\u5206\u306a\u8a18\u8f09\u304c\u7121\u304f\u3001\u57f7\u7b46\u8005\u306b\u539f\u6750\u6599\u88fd\u9020\u4f01\u696d\u306e\u793e\u54e1\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u30fb\u75c7\u4f8b\u6e1b\u5c11\u30d0\u30a4\u30a2\u30b9\u30fb\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306f\u5426\u5b9a\u3067\u304d\u306a\u3044\u3002
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