{"id":37337,"date":"2025-08-07T07:20:11","date_gmt":"2025-08-06T22:20:11","guid":{"rendered":"https:\/\/yakujihou-marketing.net\/database\/?p=37337"},"modified":"2025-11-03T12:15:50","modified_gmt":"2025-11-03T03:15:50","slug":"k151","status":"publish","type":"post","link":"https:\/\/yakujihou-marketing.net\/database\/k151\/","title":{"rendered":"\u30b0\u30df\u30fc\u30ca \u3086\u3089\u304e\u30b5\u30dd\u30fc\u30c8(K151)"},"content":{"rendered":"<table>\n<tbody>\n<tr>\n<td>\u5c4a\u51fa\u756a\u53f7<\/td>\n<td>K151<\/td>\n<\/tr>\n<tr>\n<td>\u5546\u54c1\u540d<\/td>\n<td>\u30b0\u30df\u30fc\u30ca\u3000\u3086\u3089\u304e\u30b5\u30dd\u30fc\u30c8<\/td>\n<\/tr>\n<tr>\n<td>\u5c4a\u51fa\u8005\u540d<\/td>\n<td>\u682a\u5f0f\u4f1a\u793e\u30e2\u30f3\u30c8\u30ef\u30fc\u30eb<\/td>\n<\/tr>\n<tr>\n<td>\u5c4a\u51fa\u65e5<\/td>\n<td>2025\/08\/07<\/td>\n<\/tr>\n<tr>\n<td>\u5909\u66f4\u65e5<\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<tr>\n<td>\u64a4\u56de\u65e5<\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<tr>\n<td>\u8ca9\u58f2\u4e2d<\/td>\n<td>\u8ca9\u58f2\u4f11\u6b62\u4e2d<\/td>\n<\/tr>\n<tr>\n<td>\u98df\u54c1\u306e\u533a\u5206<\/td>\n<td>\u52a0\u5de5\u98df\u54c1(\u305d\u306e\u4ed6)<\/td>\n<\/tr>\n<tr>\n<td>\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u540d<\/td>\n<td>\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001 \u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3<\/td>\n<\/tr>\n<tr>\n<td>\u8868\u793a\u3057\u3088\u3046\u3068\u3059\u308b\u6a5f\u80fd\u6027<\/td>\n<td>\u672c\u54c1\u306b\u306f\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306b\u306f\u3001\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027\u306e\u6708\u7d4c\u524d\u306e\u4e00\u6642\u7684\u306a\u6674\u308c\u306a\u3044\u6c17\u5206\u306e\u8efd\u6e1b\u3068\u7761\u7720\u306e\u8cea\uff08\u8d77\u5e8a\u6642\u306e\u7761\u7720\u306b\u5bfe\u3059\u308b\u6e80\u8db3\u611f\uff09\u306e\u5411\u4e0a\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u5f53\u8a72\u88fd\u54c1\u304c\u60f3\u5b9a\u3059\u308b\u4e3b\u306a\u5bfe\u8c61\u8005<\/td>\n<td>\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027<\/td>\n<\/tr>\n<tr>\n<td>\u4e00\u65e5\u5f53\u305f\u308a\u306e\u6442\u53d6\u76ee\u5b89\u91cf<\/td>\n<td>1\u888b\uff08\uff13\uff16\uff47\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u4e00\u65e5\u3042\u305f\u308a\u306e\u6442\u53d6\u76ee\u5b89\u91cf\u5f53\u305f\u308a\u306e\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u306e\u542b\u6709\u91cf<\/td>\n<td>\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u540d\uff1a\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3<br \/>\n\u542b\u6709\u91cf\uff1a2 mg\uff08\u5404\u6210\u52061mg\u305a\u3064\u3001\u5408\u8a082mg\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u4fdd\u5b58\u306e\u65b9\u6cd5<\/td>\n<td>\u76f4\u5c04\u65e5\u5149\u30fb\u9ad8\u6e29\u591a\u6e7f\u306e\u5834\u6240\u3092\u907f\u3051\u3066\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u6442\u53d6\u306e\u65b9\u6cd5<\/td>\n<td>1\u65e51\u888b\uff08\uff13\uff16\uff47\uff09\u3092\u76ee\u5b89\u306b\u3088\u304f\u565b\u3093\u3067\u304a\u53ec\u3057\u4e0a\u304c\u308a\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u6442\u53d6\u3092\u3059\u308b\u4e0a\u3067\u306e\u6ce8\u610f\u4e8b\u9805<\/td>\n<td>\u672c\u54c1\u306f\u3001\u591a\u91cf\u6442\u53d6\u306b\u3088\u308a\u75be\u75c5\u304c\u6cbb\u7652\u3057\u305f\u308a\u3001\u3088\u308a\u5065\u5eb7\u304c\u5897\u9032\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u3042\u308b\u65b9\u306f\u539f\u6750\u6599\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u8abf\u7406\u53c8\u306f\u4fdd\u5b58\u306e\u65b9\u6cd5\u306b\u95a2\u3057\u7279\u306b\u6ce8\u610f\u3092\u5fc5\u8981\u3068\u3059\u308b\u3082\u306e\u306b\u3042\u3063\u3066\u306f\u5f53\u8a72\u6ce8\u610f\u4e8b\u9805<\/td>\n<td>\u25cf\u958b\u5c01\u5f8c\u306f\u306a\u308b\u3079\u304f\u65e9\u3081\u306b\u304a\u53ec\u3057\u4e0a\u304c\u308a\u304f\u3060\u3055\u3044\u3002\u25cf\u9ad8\u6e29\u306e\u3068\u3053\u308d\u306b\u653e\u7f6e\u3057\u307e\u3059\u3068\u30b0\u30df\u304c\u3084\u308f\u3089\u304b\u304f\u306a\u308a\u4ed8\u7740\u3057\u305f\u308a\u3001\u5909\u5f62\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td>\u6d88\u8cbb\u8005\u5e81URL<\/td>\n<td><a href=\"https:\/\/www.fld.caa.go.jp\/caaks\/s\/cssc01\/fwccd01?c__id=a09F900004skTItIAM\" rel=\"noopener noreferrer\" target=\"_blank\">https:\/\/www.fld.caa.go.jp\/caaks\/s\/cssc01\/fwccd01?c__id=a09F900004skTItIAM<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u57fa\u672c\u60c5\u5831<\/h2>\n<h3>\u5b89\u5168\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5<\/h3>\n<p>\u25a0\u65e2\u5b58\u60c5\u5831\u306b\u3088\u308b\u5b89\u5168\u6027\u8a66\u9a13\u7d50\u679c\u306e\u8a55\u4fa1\u306b\u3088\u308a\u3001\u5341\u5206\u306a\u5b89\u5168\u6027\u3092\u78ba\u8a8d\u3057\u3066\u3044\u308b\u3002<\/p>\n<h3>\u5f53\u8a72\u88fd\u54c1\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u5c4a\u51fa\u8005\u306e\u8a55\u4fa1<\/h3>\n<p>\u4e0b\u8a18\u306e\uff08\u30a2\uff09\u3001\uff08\u30a4\uff09\u306e\u60c5\u5831\u306b\u3088\u308a\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u306e\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3092\u4e00\u65e5\u6442\u53d6\u76ee\u5b89\u91cf2 mg\uff08\u5404\u6210\u52061mg\u305a\u3064\u3001\u5408\u8a082mg\uff09\u3067\u914d\u5408\u3059\u308b\u672c\u5c4a\u51fa\u5546\u54c1\u3092\u6a5f\u80fd\u6027\u8868\u793a\u98df\u54c1\u3068\u3057\u3066\u8ca9\u58f2\u3059\u308b\u3053\u3068\u306f\u9069\u5207\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002<\/p>\n<p>\uff08\u30a2\uff09\u65e2\u5b58\u60c5\u5831\u3092\u7528\u3044\u305f\u8a55\u4fa1\u304a\u3088\u3073\u65e2\u5b58\u60c5\u5831\u306b\u3088\u308b\u5b89\u5168\u6027\u8a66\u9a13\u306e\u8a55\u4fa1<br \/>\n\u30e9\u30d5\u30de\u8449\u3092\u539f\u6599\u3068\u3057\u305f\u8336\u98f2\u6599\u300c\u71d5\u9f8d\u8336\u30ec\u30d9\u30eb\u30b1\u30a2\u300d\u306f\u7279\u5b9a\u4fdd\u5065\u7528\u98df\u54c1\u3068\u3057\u3066\u8a8d\u53ef\u3055\u308c\u3066\u3044\u308b\u3002\u300c\u71d5\u9f8d\u8336\u30ec\u30d9\u30eb\u30b1\u30a2\u300d\u306e\u4e00\u65e5\u6442\u53d6\u76ee\u5b89\u91cf\u306f500 ml\u3067\u3042\u308a\u3001\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306e\u5408\u8a08\u3068\u3057\u30661\u65e530 mg\uff08\u5404\u6210\u520615mg\u305a\u3064\uff09\u304c\u542b\u307e\u308c\u308b\u3002\uff08\u672c\u5c4a\u51fa\u5546\u54c1\u306b\u542b\u307e\u308c\u308b\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u306e\u4e00\u65e5\u6442\u53d6\u76ee\u5b89\u91cf \u5408\u8a082 mg\u306e15\u500d\u306b\u76f8\u5f53\uff09<br \/>\n\u300c\u71d5\u9f8d\u8336\u30ec\u30d9\u30eb\u30b1\u30a2\u300d\u306e\u5b89\u5168\u6027\u306b\u95a2\u3057\u3066\u306f\u3001\u907a\u4f1d\u6bd2\u6027\u3001\u52d5\u7269\u8a66\u9a13\uff08\u30de\u30a6\u30b9\u5358\u56de\u6295\u4e0e\u3001\u30e9\u30c3\u30c890\u65e5\u53cd\u5fa9\u6295\u4e0e\u3001\u30d3\u30fc\u30b0\u30eb\u72ac \u5358\u56de\u53ca\u307314\u65e5\u53cd\u5fa9\u6295\u4e0e\uff09\u3001\u30d2\u30c8\u8a66\u9a13\uff08\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u540415mg\/\u65e5\u305a\u3064\u300112\u9031\u9593\u6442\u53d6\u3001\u3082\u3057\u304f\u306f\u3001\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u540445mg\/\u65e5\u305a\u3064\u30012\uff5e4\u9031\u9593\u6442\u53d6\uff09\u306b\u304a\u3044\u3066\u8a55\u4fa1\u3055\u308c\u3001\u5b89\u5168\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002<br \/>\n\u307e\u305f\u3001\u672c\u5c4a\u51fa\u5546\u54c1\u306b\u4f7f\u7528\u3055\u308c\u308b\u30e9\u30d5\u30de\u62bd\u51fa\u7269\u3092\u7528\u3044\u305f\u30d2\u30c8\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30e9\u30d5\u30de\u62bd\u51fa\u7269250 mg\uff08\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u54045mg\/\u65e5\u3001\u672c\u5c4a\u51fa\u5546\u54c1\u306e\u4e00\u65e5\u6442\u53d6\u76ee\u5b89\u91cf\u306e5\u500d\u91cf\uff09\u30924\u9031\u9593\u6442\u53d6\u3057\u305f\u5834\u5408\u306b\u304a\u3044\u3066\u3082\u3001\u6709\u5bb3\u4e8b\u8c61\u53ca\u3073\u526f\u4f5c\u7528\u304c\u306a\u3044\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>\uff08\u30a4\uff09\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3059\u308b\u8a55\u4fa1<br \/>\n\u3010\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u691c\u7d22\u2460\u3011<br \/>\n\u691c\u7d22\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff1aPubMed<br \/>\n\u691c\u7d22\u5f0f\uff1a(Apocynum venetum) AND (drug interaction)<br \/>\n\u691c\u7d22\u65e5\uff1a2023\u5e7412\u670805\u65e5<br \/>\n\u52d5\u7269\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30e9\u30d5\u30de\u62bd\u51fa\u7269\u304cCYP2E1\u306e\u767a\u73fe\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\uff08\u53c2\u8003\u6587\u732e1\uff09\u3001\u5b9f\u969b\u306bCYP2E1\u3067\u4ee3\u8b1d\u3055\u308c\u308b\u85ac\u7269\u306e\u4f53\u5185\u52d5\u614b\u304c\u5909\u5316\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u793a\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u60c5\u5831\u304c\u4e0d\u5341\u5206\u3067\u3042\u308b\u3002<br \/>\n\u4e00\u65b9\u3067\u3001\u52d5\u7269\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u672c\u5c4a\u51fa\u5546\u54c1\u306b\u4f7f\u7528\u3055\u308c\u308b\u30e9\u30d5\u30de\u62bd\u51fa\u7269\u304cCYP3A\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u308b\u30cb\u30d5\u30a7\u30b8\u30d4\u30f3\u3084P\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4ecb\u3057\u3066\u5438\u53ce\u3055\u308c\u308b\u30e1\u30c1\u30eb\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3\u306e\u85ac\u7269\u52d5\u614b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3055\u305a\u3001CYP3A\u304a\u3088\u3073P\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u95a2\u3059\u308b\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\u3092\u6301\u305f\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\uff08\u53c2\u8003\u6587\u732e2\uff09\u3002<br \/>\n\u3010\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u691c\u7d22\u2461\u3011<br \/>\n\u691c\u7d22\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff1a\u57ce\u897f\u5927\u5b66 \u98df\u54c1-\u533b\u85ac\u54c1\u76f8\u4e92\u4f5c\u7528\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9<br \/>\n\u691c\u7d22\u30ad\u30fc\u30ef\u30fc\u30c9\uff1aApocynum venetum\u3001luobuma\u3001rafuma<br \/>\n\u691c\u7d22\u65e5\uff1a2023\u5e7412\u670806\u65e5<br \/>\n\u4e0a\u8a18\u3067\u691c\u7d22\u3057\u305f\u3068\u3053\u308d\u3001\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u7121\u304b\u3063\u305f\u3002<br \/>\n\u3010\u7dcf\u5408\u8a55\u4fa1\u3011<br \/>\n\u8abf\u67fb\u306e\u7d50\u679c\u3001\u672c\u5c4a\u51fa\u5546\u54c1\u306b\u914d\u5408\u3055\u308c\u308b\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306b\u306f\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u78ba\u8a8d\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u672c\u5c4a\u51fa\u5546\u54c1\u304c\u6442\u53d6\u306e\u5bfe\u8c61\u3068\u3057\u3066\u3044\u308b\u306e\u306f\u5065\u5e38\u8005\u3067\u3042\u308a\u3001\u533b\u85ac\u54c1\u3068\u306e\u4f75\u7528\u3092\u60f3\u5b9a\u3057\u3066\u304a\u3089\u305a\u3001\u672c\u5c4a\u51fa\u5546\u54c1\u30d1\u30c3\u30b1\u30fc\u30b8\u306b\u300c\u75be\u75c5\u306b\u7f79\u60a3\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u533b\u5e2b\u306b\u3001\u533b\u85ac\u54c1\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u533b\u5e2b\u3001\u85ac\u5264\u5e2b\u306b\u6442\u53d6\u306b\u3064\u3044\u3066\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u300d\u3068\u306e\u6ce8\u610f\u559a\u8d77\u3082\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u5065\u5eb7\u88ab\u5bb3\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002<br \/>\n\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001\u533b\u85ac\u54c1\u3092\u670d\u7528\u3057\u3066\u3044\u306a\u3044\u5065\u5e38\u8005\u304c\u9069\u5207\u306b\u6442\u53d6\u3059\u308b\u5834\u5408\u3001\u5b89\u5168\u4e0a\u554f\u984c\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002<br \/>\n\u3010\u53c2\u8003\u6587\u732e\u3011<br \/>\n1. Development of an IgY Antibody-Based Immunoassay for the Screening of the CYP2E1 Inhibitor\/Enhancer from Herbal Medicines, Frontiers in Pharmacology, 7:502 (2016)<br \/>\n2. Apocynum venetum Extract Does Not Induce CYP3A and P-Glycoprotein in Rats, Biological and Pharmaceutical Bulletin, 27(10) 1649?1652 (2004)<\/p>\n<h2>\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u57fa\u672c\u60c5\u5831<\/h2>\n<h3>\u6a5f\u80fd\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5<\/h3>\n<p>\u25a0\u6700\u7d42\u88fd\u54c1\u3067\u306f\u306a\u304f\u3001\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u306b\u95a2\u3059\u308b\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3067\u3001\u6a5f\u80fd\u6027\u3092\u8a55\u4fa1\u3057\u3066\u3044\u308b\u3002<\/p>\n<h3>\u5f53\u8a72\u88fd\u54c1\u306e\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u5c4a\u51fa\u8005\u306e\u8a55\u4fa1<\/h3>\n<p>\uff08\u30a2\uff09\u6a19\u984c<br \/>\n\u300c\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306b\u3088\u308b\u5065\u5e38\u6210\u4eba\u5973\u6027\u306e\u6708\u7d4c\u524d\u306e\u4e00\u6642\u7684\u306a\u4e0d\u8abf\u6539\u5584\u306e\u6a5f\u80fd\u6027\u306b\u3064\u3044\u3066\u300d<\/p>\n<p>\uff08\u30a4\uff09\u76ee\u7684<br \/>\n\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027\u306b\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u54041mg\/\u65e5\u3092\u6442\u53d6\u3055\u305b\u308b\u3053\u3068\u304c\u6708\u7d4c\u524d\u306e\u4e00\u6642\u7684\u306a\u4e0d\u8abf\u306e\u6539\u5584\u306b\u5f79\u7acb\u3064\u3053\u3068\u3092\u691c\u8a3c\u3057\u305f\u3002<\/p>\n<p>\uff08\u30a6\uff09\u80cc\u666f<br \/>\n\u30e9\u30d5\u30de\u8449\u306f\u53e4\u304f\u304b\u3089\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306b\u3088\u308b\u6708\u7d4c\u524d\u306e\u4e00\u6642\u7684\u306a\u4e0d\u8abf\u6539\u5584\u306e\u6a5f\u80fd\u6027\u306b\u3064\u3044\u3066\u3001\u7814\u7a76\u6210\u679c\u3092\u7dcf\u5408\u7684\u306b\u307e\u3068\u3081\u305f\u30ec\u30d3\u30e5\u30fc\u304c\u306a\u3044\u305f\u3081\u3001\u5f53\u8a72\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3092\u901a\u3058\u3066\u691c\u8a3c\u3092\u884c\u3063\u305f\u3002<\/p>\n<p>\uff08\u30a8\uff09\u30ec\u30d3\u30e5\u30fc\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306e\u7279\u6027<br \/>\nPubMed\u3001JDream\u2162\u3001\u533b\u4e2d\u8a8cWeb\u53ca\u3073UMIN-CTR\uff08\u81e8\u5e8a\u8a66\u9a13\u767b\u9332\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff09\u306e4\u3064\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304a\u3088\u3073\u30cf\u30f3\u30c9\u30b5\u30fc\u30c1\u306b\u3066\u6587\u732e\u3092\u691c\u7d22\u3057\u305f\u7d50\u679c\u30011\u5831\u306e\u6587\u732e\u3092\u63a1\u7528\u3057\u305f\u30021\u5831\u306e\u6587\u732e\u306f\u67fb\u8aad\u4ed8\u304d\u3067\u3001\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\uff08\u6708\u7d4c\u5468\u671f\u65e5\u657025\uff5e38\u65e5\uff09\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002<\/p>\n<p>\uff08\u30aa\uff09\u4e3b\u306a\u7d50\u679c<br \/>\n\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027\u306b\u3001\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3 \u54041 mg\/\u65e5\u305a\u3064\u3092\u6442\u53d6\u3055\u305b\u305f\u3002\u6708\u7d4c\u968f\u4f34\u75c7\u72b6\u65e5\u672c\u8a9e\u7248\uff08MDQ\uff09\u304a\u3088\u3073OSA\u7761\u7720\u8abf\u67fb\u7968MA\u7248\uff08OSA-MA\uff09\u3092\u7528\u3044\u305f\u8a55\u4fa1\u306e\u7d50\u679c\u3001\u4ecb\u5165\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u3079\u3001\u6708\u7d4c\u524d\u306eMDQ\u7dcf\u5f97\u70b9\uff08P=0.049\uff09\u3001MDQ\u4e0b\u4f4d\u5c3a\u5ea6\u306e\u8ca0\u306e\u611f\u60c5\uff08P=0.034\uff09OSA-MA\u306e\u5165\u7720\u3068\u7761\u7720\u7dad\u6301\uff08P=0.048\uff09\u306e\u9805\u76ee\u304c\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u3002<\/p>\n<p>\uff08\u30ab\uff09\u79d1\u5b66\u7684\u6839\u62e0\u306e\u8cea<br 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