{"id":38116,"date":"2025-09-18T08:10:53","date_gmt":"2025-09-17T23:10:53","guid":{"rendered":"https:\/\/yakujihou-marketing.net\/database\/?p=38116"},"modified":"2025-12-26T17:27:40","modified_gmt":"2025-12-26T08:27:40","slug":"k356","status":"publish","type":"post","link":"https:\/\/yakujihou-marketing.net\/database\/k356\/","title":{"rendered":"\u30a2\u30c8\u30df\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3(K356)"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u6d88\u8cbb\u8005\u5e81URL<\/td>\nhttps:\/\/www.fld.caa.go.jp\/caaks\/s\/cssc01\/fwccd01?c__id=a09RA00000GIAe1YAH<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\u25cf\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3
\n\u6587\u732e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9Pubmed\u3092\u7528\u3044\u3066\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u3092\u30d2\u30c8\u306b\u6442\u53d6\u3055\u305b\u3066\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3057\u305f\u6587\u732e\u3092\u8abf\u67fb\u3057\u305f\u3068\u3053\u308d\u3001\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306e\u5b89\u5168\u6027\u306f\u80af\u5b9a\u7684\u306b\u5224\u65ad\u3055\u308c\u3066\u304a\u308a\u3001\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u6442\u53d6\u306b\u95a2\u9023\u4ed8\u3051\u3089\u308c\u305f\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u306e\u5831\u544a\u3082\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u3092\u30a2\u30b0\u30ea\u30b3\u30f3\u63db\u7b97\u3067300 mg\/\u65e5\u30012\u5e74\u9593\u6442\u53d6\u3057\u305f\u8a66\u9a13\u3067\u5b89\u5168\u6027\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002
\n\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u306f\u3001\u8907\u6570\u306e\u533b\u85ac\u54c1\u306b\u3064\u3044\u3066\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u3068\u5171\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u4f53\u5185\u52d5\u614b\u304c\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u305f\u3002\u4e0a\u8ff0\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u3001\u305d\u306e\u5927\u534a\u306f\u30d2\u30c8\u8a66\u9a13\u306b\u3066\u78ba\u8a8d\u3055\u308c\u305f\u3082\u306e\u3067\u306f\u306a\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u306e\u4f4e\u3044\u3082\u306e\u3067\u3042\u3063\u305f\u3002\u30d2\u30c8\u8a66\u9a13\u306e\u7d50\u679c\u304b\u3089\u76f8\u4e92\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u8a00\u53ca\u3055\u308c\u3066\u3044\u308btheophylline\u304a\u3088\u3073 midazolam\u306b\u3064\u3044\u3066\u306f\u3001\u305d\u308c\u3089\u306e\u8a66\u9a13\u306b\u304a\u3051\u308b\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306e\u30a2\u30b0\u30ea\u30b3\u30f3\u63db\u7b97\u3067\u306e\u6295\u4e0e\u91cf\u304c\u3001\u672c\u5c4a\u51fa\u98df\u54c1\u306b\u542b\u307e\u308c\u308b\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306e\u30a2\u30b0\u30ea\u30b3\u30f3\u63db\u7b97\u306e1\u65e5\u5f53\u305f\u308a\u306e\u6442\u53d6\u76ee\u5b89\u91cf\u306e5\u500d\u91cf\u3092\u660e\u3089\u304b\u306b\u8d85\u3048\u308b\u904e\u5270\u91cf\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u672c\u5c4a\u51fa\u98df\u54c1\u306e\u6442\u53d6\u3068\u306f\u4e56\u96e2\u304c\u3042\u308b\u3002\u3088\u3063\u3066\u3001\u672c\u5c4a\u51fa\u98df\u54c1\u304c\u533b\u85ac\u54c1\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3068\u5224\u65ad\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u3001\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u540c\u58eb\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u78ba\u8a8d\u3055\u308c\u306a\u304b\u3063\u305f\u3002
\n\u4ee5\u4e0a\u3088\u308a\u3001\u672c\u5c4a\u51fa\u98df\u54c1\u306e\u5b89\u5168\u6027\u306b\u554f\u984c\u306f\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n

\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u57fa\u672c\u60c5\u5831<\/h2>\n

\u6a5f\u80fd\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5<\/h3>\n

\u25a0\u6700\u7d42\u88fd\u54c1\u3067\u306f\u306a\u304f\u3001\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u306b\u95a2\u3059\u308b\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3067\u3001\u6a5f\u80fd\u6027\u3092\u8a55\u4fa1\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u5f53\u8a72\u88fd\u54c1\u306e\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u5c4a\u51fa\u8005\u306e\u8a55\u4fa1<\/h3>\n

\u25cf\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3
\n\u3010\u7761\u7720\u3011
\n\uff08\u30a2\uff09\u6a19\u984c
\n\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u300c\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u300d\u306b\u3088\u308b\u7761\u7720\u306e\u8cea\u6539\u5584\u306e\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc
\n\uff08\u30a4\uff09\u76ee\u7684
\n\u6210\u4eba\u5065\u5e38\u8005\u306b\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u54041mg\/\u65e5\u3092\u6442\u53d6\u3055\u305b\u308b\u3053\u3068\u304c\u7761\u7720\u306e\u8cea(\u7720\u308a\u306e\u6df1\u3055\u30fb\u8d77\u5e8a\u6642\u306e\u7761\u7720\u306b\u5bfe\u3059\u308b\u6e80\u8db3\u611f\uff09\u306e\u5411\u4e0a\u306b\u5f79\u7acb\u3064\u3053\u3068\u3092\u691c\u8a3c\u3057\u305f\u3002
\n\uff08\u30a6\uff09\u80cc\u666f
\n\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306b\u3088\u308b\u7761\u7720\u306e\u8cea\u6539\u5584\u306e\u6a5f\u80fd\u6027\u306b\u3064\u3044\u3066\u3001\u7814\u7a76\u6210\u679c\u3092\u7dcf\u5408\u7684\u306b\u307e\u3068\u3081\u305f\u30ec\u30d3\u30e5\u30fc\u304c\u306a\u3044\u305f\u3081\u3001\u691c\u8a3c\u3092\u884c\u3063\u305f\u3002
\n\uff08\u30a8\uff09\u30ec\u30d3\u30e5\u30fc\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306e\u7279\u6027
\nPubMed\uff08\u5916\u56fd\u8a9e\u8ad6\u6587\uff09\u3001JDream\u2162\uff08\u65e5\u672c\u8a9e\u8ad6\u6587\uff09\u3001\u533b\u4e2d\u8a8cWeb\uff08\u5916\u56fd\u8a9e\u30fb\u65e5\u672c\u8a9e\u8ad6\u6587\uff09\u53ca\u3073UMIN-CTR\uff08\u81e8\u5e8a\u8a66\u9a13\u767b\u9332\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff09\u306e4\u3064\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u691c\u7d22\u3057\u305f\u7d50\u679c\u30013\u5831\u306e\u6587\u732e\u3092\u63a1\u7528\u3057\u305f\u30023\u5831\u306e\u6587\u732e\u306f\u3044\u305a\u308c\u3082\u67fb\u8aad\u4ed8\u304d\u3067\u3001\u5065\u5e38\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002
\n\uff08\u30aa\uff09\u4e3b\u306a\u7d50\u679c
\n\u5065\u5e38\u6210\u4eba\u306b\u3001\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3 \u54041mg\/\u65e5\u305a\u3064\u3092\u6442\u53d6\u3055\u305b\u305f\u30021\u5831\u306e\u6587\u732e\u3067\u4ecb\u5165\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u3079\u3001\u7dcf\u7761\u7720\u6642\u9593\u306b\u5bfe\u3059\u308b\u76f8\u5bfe\u7684\u306a\u30ce\u30f3\u30ec\u30e0\u7761\u7720\u306e\u6642\u9593\u5272\u5408\u304c\u6442\u53d6\u524d\u5f8c\u3067\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\uff08p=0.01\uff09\u30022\u5831\u306e\u6587\u732e\u3067\u4ecb\u5165\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u3079\u3001OSA\u7761\u7720\u8abf\u67fb\u7968MA\u7248\u306e\u5165\u7720\u3068\u7761\u7720\u7dad\u6301\u306e\u9805\u76ee\u304c\u6442\u53d6\u524d\u5f8c\u3067\u6709\u610f\u306b\u6539\u5584\u3057\u305f\uff08p=0.042\u3001p=0.048\uff09\u3002
\n\uff08\u30ab\uff09\u79d1\u5b66\u7684\u6839\u62e0\u306e\u8cea
\n\u30fb\u7761\u7720\u306e\u8cea\u6539\u5584\uff08\u7720\u308a\u306e\u6df1\u3055\uff09
\n\u63a1\u7528\u6587\u732eNo.1\u306b\u304a\u3044\u3066\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u306f\u4e2d\u7a0b\u5ea6\u3067\u3042\u308b\u3068\u5224\u65ad\u3057\u305f\u3002\u5bfe\u8c61\u3001\u4ecb\u5165\u3001\u5bfe\u7167\u304a\u3088\u3073\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u672c\u30ec\u30d3\u30e5\u30fc\u306e\u30ea\u30b5\u30fc\u30c1\u30af\u30a8\u30b9\u30c1\u30e7\u30f3\u306b\u4e56\u96e2\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u975e\u76f4\u63a5\u6027\u306f\u8a8d\u3081\u3089\u308c\u306a\u3044\u3068\u8a55\u4fa1\u3057\u305f\u3002\u5f53\u8a72\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u5831\u544a\u306f1\u5831\u306e\u307f\u3060\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u975e\u4e00\u8cab\u6027\u306b\u3064\u3044\u3066\u306f\u4e2d\u7a0b\u5ea6\u3068\u3057\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5341\u5206\u3067\u306a\u3044\u3053\u3068\u304b\u3089\u3001\u4e0d\u7cbe\u78ba\u306b\u3064\u3044\u3066\u3082\u4e2d\u7a0b\u5ea6\u3001\u672a\u767a\u8868\u30c7\u30fc\u30bf\u306e\u5b58\u5728\u304c\u5426\u5b9a\u3067\u304d\u306a\u3044\u3053\u3068\u304b\u3089\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306b\u3064\u3044\u3066\u3082\u4e2d\u7a0b\u5ea6\u3068\u8a55\u4fa1\u3057\u305f\u3002\u4ee5\u4e0a\u3092\u8e0f\u307e\u3048\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u78ba\u5b9f\u6027\u306f\u300c\u4e2d\uff08B\uff09\u300d\u3068\u8a55\u4fa1\u3057\u305f\u3002
\n\u30fb\u7761\u7720\u306e\u8cea\u6539\u5584\uff08\u8d77\u5e8a\u6642\u306e\u7761\u7720\u306b\u5bfe\u3059\u308b\u6e80\u8db3\u611f\uff09\uff09
\n\u63a1\u7528\u6587\u732e3\u5831\u306b\u304a\u3044\u3066\u5168\u4f53\u3068\u3057\u3066\u306e\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u306f\u4e2d\u7a0b\u5ea6\u3067\u3042\u308b\u3068\u5224\u65ad\u3057\u305f\u3002\u63a1\u7528\u6587\u732e3\u5831\u306b\u304a\u3051\u308b\u5bfe\u8c61\u3001\u4ecb\u5165\u3001\u5bfe\u7167\u304a\u3088\u3073\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u672c\u30ec\u30d3\u30e5\u30fc\u306e\u30ea\u30b5\u30fc\u30c1\u30af\u30a8\u30b9\u30c1\u30e7\u30f3\u306b\u4e56\u96e2\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u975e\u76f4\u63a5\u6027\u306f\u8a8d\u3081\u3089\u308c\u306a\u3044\u3068\u8a55\u4fa1\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u7761\u7720\u306e\u8cea\u3092\u6539\u5584\u3059\u308b\u4f5c\u7528\u304c\u8a8d\u3081\u3089\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u975e\u4e00\u8cab\u6027\u306b\u3064\u3044\u3066\u306f\u4f4e\u3044\u3068\u8a55\u4fa1\u3057\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c50\u540d\u4ee5\u4e0a\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u4e0d\u7cbe\u78ba\u306b\u3064\u3044\u3066\u3082\u4f4e\u3044\u3068\u8a55\u4fa1\u3057\u305f\u3002\u672a\u767a\u8868\u30c7\u30fc\u30bf\u306e\u5b58\u5728\u304c\u5426\u5b9a\u3067\u304d\u306a\u3044\u3053\u3068\u304b\u3089\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306b\u3064\u3044\u3066\u306f\u4e2d\u7a0b\u5ea6\u3068\u8a55\u4fa1\u3057\u305f\u3002\u4ee5\u4e0a\u3092\u8e0f\u307e\u3048\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u78ba\u5b9f\u6027\u306f\u300c\u9ad8\uff08A\uff09\u300d\u3068\u8a55\u4fa1\u3057\u305f\u3002
\n\u4ee5\u4e0a\u3088\u308a\u3001\u672c\u5c4a\u51fa\u5546\u54c1\u306b\u914d\u5408\u3059\u308b\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3092\u54041mg\/\u65e5\u305a\u3064\u6442\u53d6\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u7761\u7720\u306e\u8cea(\u7720\u308a\u306e\u6df1\u3055\u30fb\u8d77\u5e8a\u6642\u306e\u7761\u7720\u306b\u5bfe\u3059\u308b\u6e80\u8db3\u611f\uff09\u306e\u5411\u4e0a\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u898b\u8fbc\u307e\u308c\u3001\u8868\u793a\u3057\u3088\u3046\u3068\u3059\u308b\u6a5f\u80fd\u6027\u306f\u9069\u5207\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002
\n\u3010\u6674\u308c\u306a\u3044\u6c17\u5206\u3011
\n\uff08\u30a2\uff09\u6a19\u984c
\n\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u300c\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u300d\u306b\u3088\u308b\u6708\u7d4c\u524d\u306e\u4e00\u6642\u7684\u306a\u4e0d\u8abf\u6539\u5584\u306e\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc
\n\uff08\u30a4\uff09\u76ee\u7684
\n\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027\u306b\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u54041mg\/\u65e5\u3092\u6442\u53d6\u3055\u305b\u308b\u3053\u3068\u304c\u6708\u7d4c\u524d\u306e\u4e00\u6642\u7684\u306a\u4e0d\u8abf\u306e\u6539\u5584\u306b\u5f79\u7acb\u3064\u3053\u3068\u3092\u691c\u8a3c\u3057\u305f\u3002
\n\uff08\u30a6\uff09\u80cc\u666f
\n\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u3001\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u306b\u3088\u308b\u6708\u7d4c\u524d\u306e\u4e00\u6642\u7684\u306a\u4e0d\u8abf\u6539\u5584\u306e\u6a5f\u80fd\u6027\u306b\u3064\u3044\u3066\u3001\u7814\u7a76\u6210\u679c\u3092\u7dcf\u5408\u7684\u306b\u307e\u3068\u3081\u305f\u30ec\u30d3\u30e5\u30fc\u304c\u306a\u3044\u305f\u3081\u3001\u691c\u8a3c\u3092\u884c\u3063\u305f\u3002
\n\uff08\u30a8\uff09\u30ec\u30d3\u30e5\u30fc\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306e\u7279\u6027
\nPubMed\u3001JDream\u2162\u3001\u533b\u4e2d\u8a8cWeb\u53ca\u3073UMIN-CTR\uff08\u81e8\u5e8a\u8a66\u9a13\u767b\u9332\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff09\u306e4\u3064\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304a\u3088\u3073\u30cf\u30f3\u30c9\u30b5\u30fc\u30c1\u306b\u3066\u6587\u732e\u3092\u691c\u7d22\u3057\u305f\u7d50\u679c\u30011\u5831\u306e\u6587\u732e\u3092\u63a1\u7528\u3057\u305f\u30021\u5831\u306e\u6587\u732e\u306f\u67fb\u8aad\u4ed8\u304d\u3067\u3001\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\uff08\u6708\u7d4c\u5468\u671f\u65e5\u657025\uff5e38\u65e5\uff09\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002
\n\uff08\u30aa\uff09\u4e3b\u306a\u7d50\u679c
\n\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027\u306b\u3001\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3 \u54041 mg\/\u65e5\u305a\u3064\u3092\u6442\u53d6\u3055\u305b\u305f\u3002\u6708\u7d4c\u968f\u4f34\u75c7\u72b6\u65e5\u672c\u8a9e\u7248\uff08MDQ\uff09\u3092\u7528\u3044\u305f\u8a55\u4fa1\u306e\u7d50\u679c\u3001\u4ecb\u5165\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u3079\u3001\u6708\u7d4c\u524d\u306eMDQ\u7dcf\u5f97\u70b9\uff08P=0.049\uff09\u3001MDQ\u4e0b\u4f4d\u5c3a\u5ea6\u306e\u8ca0\u306e\u611f\u60c5\uff08P=0.034\uff09\u304c\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u3002
\n\uff08\u30ab\uff09\u79d1\u5b66\u7684\u6839\u62e0\u306e\u8cea
\n\u63a1\u7528\u6587\u732e\u306b\u304a\u3044\u3066\u5168\u4f53\u306e\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u3068\u3057\u3066\u306f\u300c\u4e2d\uff08-1\uff09\u300d\u3068\u5224\u65ad\u3057\u305f\u3002\u975e\u76f4\u63a5\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u672c\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3068\u63a1\u7528\u6587\u732e\u306e\u5bfe\u8c61\u8005\u306e\u5c5e\u6027\u3084\u3001\u4ecb\u5165\u30fb\u5bfe\u7167\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u304c\u4e00\u81f4\u3057\u3066\u3044\u308b\u305f\u3081\u300c\u4f4e\uff080\uff09\u300d\u3068\u5224\u65ad\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001\u672c\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u306e\u9650\u754c\u3068\u3057\u3066\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u305f\u3081\u4e0d\u7cbe\u78ba\u306f\u300c\u4e2d\uff08-1\uff09\u300d\u3001\u80af\u5b9a\u7684\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u3082\u306e\u306e\u63a1\u7528\u6587\u732e\u304c1\u5831\u306e\u307f\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u975e\u4e00\u8cab\u6027\u306f\u300c\u4e2d\uff08-1\uff09\u300d\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306e\u53ef\u80fd\u6027\u306f\u5426\u5b9a\u3067\u304d\u306a\u3044\u305f\u3081\u300c\u4e2d\uff08-1\uff09\u300d\u3067\u3042\u308b\u3053\u3068\u3092\u8e0f\u307e\u3048\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u78ba\u5b9f\u6027\u306f\u300c\u4e2d\uff08B\uff09\u300d\u3068\u8a55\u4fa1\u3057\u305f\u3002
\n\u4ee5\u4e0a\u3088\u308a\u3001\u672c\u5c4a\u51fa\u5546\u54c1\u306b\u914d\u5408\u3059\u308b\u30e9\u30d5\u30de\u7531\u6765\u30d2\u30da\u30ed\u30b7\u30c9\u53ca\u3073\u30e9\u30d5\u30de\u7531\u6765\u30a4\u30bd\u30af\u30a8\u30eb\u30b7\u30c8\u30ea\u30f3\u3092\u54041mg\/\u65e5\u305a\u3064\u6442\u53d6\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u6708\u7d4c\u5468\u671f\u304c\u6b63\u5e38\u306a\u5065\u5e38\u6210\u4eba\u5973\u6027\u306e\u6708\u7d4c\u524d\u306e\u4e00\u6642\u7684\u306a\u6674\u308c\u306a\u3044\u6c17\u5206\u306e\u6539\u5584\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u898b\u8fbc\u307e\u308c\u3001\u8868\u793a\u3057\u3088\u3046\u3068\u3059\u308b\u6a5f\u80fd\u6027\u306f\u9069\u5207\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002
\n\u25cf\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3
\n\uff08\u30a2\uff09\u6a19\u984c
\n\u6700\u7d42\u88fd\u54c1\u306b\u542b\u307e\u308c\u308b\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306b\u3088\u308b\u9aa8\u5438\u53ce\u6291\u5236\u4f5c\u7528\u306b\u95a2\u3059\u308b\u7814\u7a76\u30ec\u30d3\u30e5\u30fc
\n\uff08\u30a4\uff09\u76ee\u7684
\n\u5065\u5e38\u306a\u65e5\u672c\u4eba\u6210\u4eba\u306b\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u309230 mg(\u30a2\u30b0\u30ea\u30b3\u30f3\u63db\u7b97)\/\u65e5\u4ee5\u4e0b\u3067\u6442\u53d6\u3055\u305b\u308b\u3068\u9aa8\u5438\u53ce\u304c\u6291\u5236\u3055\u308c\u308b\u304b\u691c\u8a3c\u3059\u3079\u304f\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3057\u305f\u3002
\n\uff08\u30a6\uff09\u80cc\u666f
\n\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306e\u9aa8\u5438\u53ce\u30de\u30fc\u30ab\u30fc\u306e\u4f4e\u4e0b\u4f5c\u7528\u306b\u3064\u3044\u3066\u8907\u6570\u306e\u8ad6\u6587\u5831\u544a\u304c\u3042\u308b\u3082\u306e\u306e\u3001\u5bfe\u8c61\u3092\u5065\u5e38\u306a\u65e5\u672c\u4eba\u6210\u4eba\u3068\u3057\u3066\u7db2\u7f85\u7684\u306b\u89e3\u6790\u3057\u305f\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u306f\u898b\u3064\u304b\u3089\u306a\u304b\u3063\u305f\u3002\u305d\u3053\u3067\u5065\u5e38\u306a\u65e5\u672c\u4eba\u6210\u4eba\u306b\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u3092\u6442\u53d6\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308b\u9aa8\u5438\u53ce\u306b\u53ca\u307c\u3059\u4f5c\u7528\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u672c\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3057\u305f\u3002
\n\uff08\u30a8\uff09\u30ec\u30d3\u30e5\u30fc\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306e\u7279\u6027
\n\u5065\u5e38\u306a\u65e5\u672c\u4eba\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3001\u9aa8\u5438\u53ce\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u5c3f\u4e2d\u30c7\u30aa\u30ad\u30b7\u30d4\u30ea\u30b8\u30ce\u30ea\u30f3\uff08DPD\uff09\u306b\u3064\u3044\u3066\u3001\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f330 mg(\u30a2\u30b0\u30ea\u30b3\u30f3\u63db\u7b97)\/\u65e5\u4ee5\u4e0b\u306e\u6442\u53d6\u3068\u30d7\u30e9\u30bb\u30dc\u6442\u53d6\u3092\u6bd4\u8f03\u3057\u3066\u3044\u308b\u67fb\u8aad\u4ed8\u304d\u8ad6\u6587\u3092\u63a1\u7528\u3057\u305f\u3002\u65e5\u672c\u8a9e\u53ca\u3073\u82f1\u8a9e\u306e\u81e8\u5e8a\u8ad6\u6587\u3092\u3001\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u7528\u3044\u3066\u691c\u7d22\u3057\u30018\u5831\u3092\u63a1\u7528\u3057\u305f\u3002
\n\uff08\u30aa\uff09\u4e3b\u306a\u7d50\u679c
\n\u63a1\u7528\u3057\u305f\u8ad6\u6587\u306f\u3001\u3044\u305a\u308c\u3082\u5065\u5e38\u306a\u65e5\u672c\u4eba\u4e2d\u9ad8\u5e74\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u3066\u304a\u308a\u3001\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306e\u6442\u53d6\u91cf\u306f23.3\uff5e26.9 mg(\u30a2\u30b0\u30ea\u30b3\u30f3\u63db\u7b97)\u3001\u6442\u53d6\u671f\u9593\u306f2\uff5e10\u9031\u9593\u3067\u3042\u3063\u305f\u30028\u5831\u4e2d7\u5831\u3067\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306e\u6442\u53d6\u524d\u5f8c\u306e\u6bd4\u8f03\u3067\u5c3f\u4e2dDPD\u91cf\u306e\u6709\u610f\u306a\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u305f\u30028\u5831\u4e2d1\u5831\u3067\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u7fa4\u306b\u304a\u3044\u3066\u5c3f\u4e2dDPD\u91cf\u306e\u6709\u610f\u306a\u4f4e\u5024\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u307e\u305f\u30018\u5831\u4e2d1\u5831\u3067\u306f\u6442\u53d6\u524d\u5f8c\u306e\u5c3f\u4e2dDPD\u5909\u5316\u7387\u306b\u3064\u3044\u3066\u3001\u9589\u7d4c\u5f8c\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5c64\u5225\u89e3\u6790\u3067\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u7fa4\u306b\u304a\u3044\u3066\u6709\u610f\u306a\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002
\n\uff08\u30ab\uff09\u79d1\u5b66\u7684\u6839\u62e0\u306e\u8cea
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