{"id":38522,"date":"2025-09-30T09:30:42","date_gmt":"2025-09-30T00:30:42","guid":{"rendered":"https:\/\/yakujihou-marketing.net\/database\/?p=38522"},"modified":"2026-02-05T12:21:47","modified_gmt":"2026-02-05T03:21:47","slug":"k459","status":"publish","type":"post","link":"https:\/\/yakujihou-marketing.net\/database\/k459\/","title":{"rendered":"\uff2e\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u30bf\u30d6\u30ec\u30c3\u30c8\uff2d(K459)"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u5c4a\u51fa\u756a\u53f7<\/td>\nK459<\/td>\n<\/tr>\n
\u5546\u54c1\u540d<\/td>\n\uff2e\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u30bf\u30d6\u30ec\u30c3\u30c8\uff2d<\/td>\n<\/tr>\n
\u5c4a\u51fa\u8005\u540d<\/td>\n\u682a\u5f0f\u4f1a\u793e\u6771\u6d0b\u65b0\u85ac<\/td>\n<\/tr>\n
\u5c4a\u51fa\u65e5<\/td>\n2025\/09\/30<\/td>\n<\/tr>\n
\u5909\u66f4\u65e5<\/td>\n–<\/td>\n<\/tr>\n
\u64a4\u56de\u65e5<\/td>\n–<\/td>\n<\/tr>\n
\u8ca9\u58f2\u4e2d<\/td>\n\u8ca9\u58f2\u4f11\u6b62\u4e2d<\/td>\n<\/tr>\n
\u98df\u54c1\u306e\u533a\u5206<\/td>\n\u52a0\u5de5\u98df\u54c1(\u9320\u5264\u3001\u30ab\u30d7\u30bb\u30eb\u5264\u7b49)<\/td>\n<\/tr>\n
\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u540d<\/td>\nN-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3<\/td>\n<\/tr>\n
\u8868\u793a\u3057\u3088\u3046\u3068\u3059\u308b\u6a5f\u80fd\u6027<\/td>\n\u672c\u54c1\u306b\u306f\u3001N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u304c\u542b\u307e\u308c\u307e\u3059\u3002N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u306b\u306f\u3001\u4e2d\u9ad8\u5e74\u306e\u65b9\u306e\u524d\u5411\u304d\u306a\u6c17\u5206\uff08\u6d3b\u6c17\u30fb\u6d3b\u529b\u611f\uff09\u3092\u7dad\u6301\u3059\u308b\u6a5f\u80fd\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/td>\n<\/tr>\n
\u5f53\u8a72\u88fd\u54c1\u304c\u60f3\u5b9a\u3059\u308b\u4e3b\u306a\u5bfe\u8c61\u8005<\/td>\n\u5065\u5e38\u306a\u4e2d\u9ad8\u5e74\u306e\u65b9<\/td>\n<\/tr>\n
\u4e00\u65e5\u5f53\u305f\u308a\u306e\u6442\u53d6\u76ee\u5b89\u91cf<\/td>\n1\u65e5\u5f53\u305f\u308a1\u7c92\u3092\u76ee\u5b89\u306b\u304a\u53ec\u3057\u4e0a\u304c\u308a\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n
\u4e00\u65e5\u3042\u305f\u308a\u306e\u6442\u53d6\u76ee\u5b89\u91cf\u5f53\u305f\u308a\u306e\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u306e\u542b\u6709\u91cf<\/td>\n\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u540d\uff1aN-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3
\n\u542b\u6709\u91cf\uff1a8.8 mg<\/td>\n<\/tr>\n
\u4fdd\u5b58\u306e\u65b9\u6cd5<\/td>\n\u9ad8\u6e29\u3001\u591a\u6e7f\u53ca\u3073\u76f4\u5c04\u65e5\u5149\u3092\u907f\u3051\u3066\u4fdd\u5b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n
\u6442\u53d6\u306e\u65b9\u6cd5<\/td>\n\u565b\u307e\u305a\u306b\u3001\u6c34\u307e\u305f\u306f\u306c\u308b\u307e\u6e6f\u3067\u304a\u53ec\u3057\u4e0a\u304c\u308a\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n
\u6442\u53d6\u3092\u3059\u308b\u4e0a\u3067\u306e\u6ce8\u610f\u4e8b\u9805<\/td>\n\u591a\u91cf\u6442\u53d6\u306b\u3088\u308a\u75be\u75c5\u304c\u6cbb\u7652\u3057\u305f\u308a\u3001\u3088\u308a\u5065\u5eb7\u304c\u5897\u9032\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\uff11\u65e5\u306e\u6442\u53d6\u76ee\u5b89\u91cf\u3092\u304a\u5b88\u308a\u304f\u3060\u3055\u3044\u3002\u598a\u5a20\u4e2d\u306e\u65b9\u3042\u308b\u3044\u306f\u598a\u5a20\u306e\u53ef\u80fd\u6027\u306e\u3042\u308b\u65b9\u306f\u533b\u5e2b\u306b\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/td>\n<\/tr>\n
\u8abf\u7406\u53c8\u306f\u4fdd\u5b58\u306e\u65b9\u6cd5\u306b\u95a2\u3057\u7279\u306b\u6ce8\u610f\u3092\u5fc5\u8981\u3068\u3059\u308b\u3082\u306e\u306b\u3042\u3063\u3066\u306f\u5f53\u8a72\u6ce8\u610f\u4e8b\u9805<\/td>\n\u7121<\/td>\n<\/tr>\n
\u6d88\u8cbb\u8005\u5e81URL<\/td>\nhttps:\/\/www.fld.caa.go.jp\/caaks\/s\/cssc01\/fwccd01?c__id=a09RA00000Ht6xRYAR<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u57fa\u672c\u60c5\u5831<\/h2>\n

\u5b89\u5168\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5<\/h3>\n

\u25a0\u65e2\u5b58\u60c5\u5831\u306b\u3088\u308b\u5b89\u5168\u6027\u8a66\u9a13\u7d50\u679c\u306e\u8a55\u4fa1\u306b\u3088\u308a\u3001\u5341\u5206\u306a\u5b89\u5168\u6027\u3092\u78ba\u8a8d\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u5f53\u8a72\u88fd\u54c1\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u5c4a\u51fa\u8005\u306e\u8a55\u4fa1<\/h3>\n

\uff08\u30a2\uff09\u65e2\u5b58\u60c5\u5831\u306b\u3088\u308b\u5b89\u5168\u6027\u8a66\u9a13\u306e\u8a55\u4fa1
\n\u672c\u54c1\u306e\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u3092\u542b\u3080\u539f\u6750\u6599\u3068\u540c\u4e00\u3067\u3042\u308b\u300cN-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u300d\u3092\u4f7f\u7528\u3057\u305fin vitro\u5fa9\u5e30\u7a81\u7136\u5909\u7570\u8a66\u9a13\u3001in vitro\u5c0f\u6838\u8a66\u9a13\u3001\u6025\u6027\u6bd2\u6027\u8a66\u9a13\u3001\u4e9c\u6162\u6027\u6bd2\u6027\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u3044\u305a\u308c\u3082\u9670\u6027\u307e\u305f\u306f\u6bd2\u6027\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u5065\u5e38\u6210\u4eba\u7537\u597315\u540d\u3092\u5bfe\u8c61\u306b\u3001\u300cN-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u300d\uff08N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f318.5 mg\/\u65e5\uff09\u3092\u542b\u6709\u3059\u308b\u9320\u5264\u309212\u9031\u9593\u3001\u7d9a\u3044\u30665\u500d\u91cf\uff08N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f392.5 mg\/\u65e5\uff09\u30924\u9031\u9593\u3001\u8a0816\u9031\u9593\u6442\u53d6\u3055\u305b\u305f\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u81e8\u5e8a\u4e0a\u554f\u984c\u3068\u306a\u308b\u691c\u67fb\u5024\u306e\u5909\u52d5\u53ca\u3073\u8a66\u9a13\u98df\u54c1\u3068\u56e0\u679c\u95a2\u4fc2\u306e\u3042\u308b\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u73fe\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\u3001\u672c\u54c1\u306e\u6442\u53d6\u306b\u304a\u3044\u3066\u5b89\u5168\u6027\u306b\u554f\u984c\u306f\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n

\uff08\u30a4\uff09\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3059\u308b\u8a55\u4fa1
\n\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u53ca\u3073\u6587\u732e\u8abf\u67fb\u306e\u7d50\u679c\u3001N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u306f\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3057\u3066\u61f8\u5ff5\u3068\u306a\u308b\u60c5\u5831\u306f\u306a\u304b\u3063\u305f\u3002<\/p>\n

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\n\u4ee5\u4e0a\u3088\u308a\u3001\u672c\u54c1\u306e\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u3092\u542b\u3080\u539f\u6750\u6599\u306f\u3001\u5b89\u5168\u6027\u306b\u61f8\u5ff5\u306f\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u305f\u3002\u307e\u305f\u3001\u4ed6\u306e\u539f\u6750\u6599\u306f\u672c\u54c1\u306e\u914d\u5408\u91cf\u3067\u5b89\u5168\u6027\u306b\u554f\u984c\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u3088\u3063\u3066\u3001\u672c\u54c1\u3092\u9069\u5207\u306b\u6442\u53d6\u3059\u308b\u4e0a\u3067\u5b89\u5168\u6027\u306b\u554f\u984c\u306f\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n

\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u57fa\u672c\u60c5\u5831<\/h2>\n

\u6a5f\u80fd\u6027\u306e\u8a55\u4fa1\u65b9\u6cd5<\/h3>\n

\u25a0\u6700\u7d42\u88fd\u54c1\u3067\u306f\u306a\u304f\u3001\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u306b\u95a2\u3059\u308b\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u3067\u3001\u6a5f\u80fd\u6027\u3092\u8a55\u4fa1\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u5f53\u8a72\u88fd\u54c1\u306e\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u5c4a\u51fa\u8005\u306e\u8a55\u4fa1<\/h3>\n

\uff08\u30a2\uff09\u6a19\u984c
\nN-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u304c\u4e2d\u9ad8\u5e74\u5065\u5e38\u8005\u306e\u524d\u5411\u304d\u306a\u6c17\u5206\uff08\u6d3b\u6c17\u30fb\u6d3b\u529b\u611f\uff09\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/p>\n

\uff08\u30a4\uff09\u76ee\u7684
\n\u4e2d\u9ad8\u5e74\u5065\u5e38\u8005\u306b\u304a\u3044\u3066\u3001N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u306e\u6442\u53d6\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u306e\u6442\u53d6\u3068\u6bd4\u8f03\u3057\u3066\u3001\u524d\u5411\u304d\u306a\u6c17\u5206\uff08\u6d3b\u6c17\u30fb\u6d3b\u529b\u611f\uff09\u3092\u7dad\u6301\u3059\u308b\u6a5f\u80fd\u3092\u6709\u3059\u308b\u304b\u691c\u8a3c\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002<\/p>\n

\uff08\u30a6\uff09\u80cc\u666f
\nN-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u306f\u3001\u30aa\u30ec\u30ad\u30b7\u30f3\u7523\u751f\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u751f\u6210\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3001\u52d5\u7269\u306b\u304a\u3044\u3066\u526f\u4ea4\u611f\u795e\u7d4c\u6d3b\u52d5\u3092\u5897\u9032\u3055\u305b\u305f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u4ee5\u4e0a\u306e\u77e5\u898b\u304b\u3089\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u3082N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u306b\u3088\u308b\u6c17\u5206\u72b6\u614b\u306e\u6539\u5584\u3084\u524d\u5411\u304d\u306a\u6c17\u5206\u306e\u7dad\u6301\u304c\u671f\u5f85\u3055\u308c\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u306e\u524d\u5411\u304d\u306a\u6c17\u5206\uff08\u6d3b\u6c17\u30fb\u6d3b\u529b\u611f\uff09\u3092\u7dad\u6301\u3059\u308b\u6a5f\u80fd\u306b\u95a2\u3057\u3066\u3001\u6700\u65b0\u306e\u81e8\u5e8a\u7814\u7a76\u306e\u5831\u544a\u3082\u542b\u3081\u3066\u7db2\u7f85\u7684\u306b\u8abf\u3079\u305f\u7814\u7a76\u306f\u898b\u5f53\u305f\u3089\u306a\u3044\u3053\u3068\u304b\u3089\u3001\u672c\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/p>\n

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\n\u4e2d\u9ad8\u5e74\u5065\u5e38\u8005\u3092\u5bfe\u8c61\u306b\u3001N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f3\u306e\u6442\u53d6\u306b\u3088\u308b\u524d\u5411\u304d\u306a\u6c17\u5206\uff08\u6d3b\u6c17\u30fb\u6d3b\u529b\u611f\uff09\u3092\u7dad\u6301\u3059\u308b\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u3092\u3001\u30d7\u30e9\u30bb\u30dc\u306e\u6442\u53d6\u3068\u6bd4\u8f03\u3057\u305f\u8ad6\u6587\u3092\u8a55\u4fa1\u5bfe\u8c61\u3068\u3057\u305f\u3002\u6587\u732e\u691c\u7d22\u3057\u3001\u8ad6\u6587\u306e\u5185\u5bb9\u3092\u7cbe\u67fb\u3057\u305f\u3068\u3053\u308d\u3001\u63a1\u7528\u6587\u732e\u306f1\u5831\u3068\u306a\u3063\u305f\u3002<\/p>\n

\uff08\u30aa\uff09\u4e3b\u306a\u7d50\u679c
\n\u5065\u5e38\u306a\u4e2d\u9ad8\u5e74\u7537\u5973\u306b\u304a\u3044\u3066\u3001N-\u30a2\u30bb\u30c1\u30eb\u30de\u30f3\u30ce\u30b5\u30df\u30f38.8 mg\/\u65e5\u3092\u6442\u53d6\u3055\u305b\u305f\u7d50\u679c\u3001\u30d7\u30e9\u30bb\u30dc\u306e\u6442\u53d6\u3068\u6bd4\u8f03\u3057\u3066\u3001POMS2\uff3b\u6d3b\u6c17-\u6d3b\u529b\uff3d\u306b\u3064\u3044\u3066\u6709\u610f\u306a\u5dee\u304c\u8a8d\u3081\u3089\u308c\uff08p < 0.05\uff09\u3001\u80af\u5b9a\u7684\u306a\u7d50\u679c\u3067\u3042\u3063\u305f\u3002<\/p>\n

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