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\u6d88\u8cbb\u8005\u5e81URL<\/td>\nhttps:\/\/www.fld.caa.go.jp\/caaks\/s\/cssc01\/fwccd01?c__id=a09RA00000IITSkYAP<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\n\u3010\u76ee\u7684\u3011
\n\u5065\u5e38\u6210\u4eba\uff08P\uff09\u304c\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u3092\u7d4c\u53e3\u6442\u53d6\uff08I\uff09\u3059\u308b\u3053\u3068\u3067\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\uff08C\uff09\u98df\u5f8c\u306e\u4e2d\u6027\u8102\u80aa\u4e0a\u6607\u3092\u6291\u5236\uff08O\uff09\u3067\u304d\u308b\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002
\n\u3010\u80cc\u666f\u3011
\n\u98df\u5f8c\u306b\u4e2d\u6027\u8102\u80aa\u306e\u9ad8\u3044\u72b6\u614b\u304c\u9577\u6642\u9593\u7d99\u7d9a\u3059\u308b\u3053\u3068\u306f\u52d5\u8108\u786c\u5316\u3084\u51a0\u52d5\u8108\u75be\u60a3\u306e\u767a\u75c7\u3092\u65e9\u3081\u308b\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u3002\u98df\u7269\u7e4a\u7dad\u306b\u306f\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u3092\u6291\u5236\u3059\u308b\u6a5f\u80fd\u3092\u6709\u3059\u308b\u3082\u306e\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u306b\u3082\u305d\u306e\u6a5f\u80fd\u304c\u671f\u5f85\u3055\u308c\u308b\u3002\u305d\u3053\u3067\u4eca\u56de\u3001\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u306e\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u4e0a\u6607\u6291\u5236\u4f5c\u7528\u306b\u95a2\u3059\u308b\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3057\u305f\u3002
\n\u3010\u30ec\u30d3\u30e5\u30fc\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u306e\u7279\u6027\u3011
\n\u56fd\u5185\u5916\u306e\u6587\u732e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u5bfe\u8c61\u306b\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u306e\u5065\u5e38\u6210\u4eba\u306b\u5bfe\u3059\u308b\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u6291\u5236\u4f5c\u7528\u306b\u3064\u3044\u3066\u8abf\u67fb\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u3092\u8a55\u4fa1\u5bfe\u8c61\u3068\u3057\u305f\u6587\u732e\u691c\u7d22\u3001\u30cf\u30f3\u30c9\u30b5\u30fc\u30c1\u3068\u3057\u3066\u6a5f\u80fd\u6027\u8868\u793a\u98df\u54c1\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u53ce\u8f09\u3055\u308c\u305f\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u306b\u95a2\u3059\u308b\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3092\u5bfe\u8c61\u306b\u691c\u7d22\u3092\u5b9f\u65bd\u3057\uff08\u3044\u305a\u308c\u3082\u691c\u7d22\u65e5\uff1a 2025\u5e746\u670817\u65e5\u3001\u691c\u7d22\u5bfe\u8c61\u671f\u9593\uff1a\uff5e2025\u5e746\u670817\u65e5\uff09\u3001\u5831\u544a\u5185\u5bb9\u3092\u7cbe\u67fb\u3057\u305f\u7d50\u679c\u3001\u63a1\u7528\u6587\u732e\u306f1\u5831\u3068\u306a\u3063\u305f\u3002\u63a1\u7528\u6587\u732e\u3067\u306f\u3001\u5065\u5e38\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30af\u30ed\u30b9\u30aa\u30fc\u30d0\u30fc\u8a66\u9a13\u306b\u3066\u9ad8\u8102\u80aa\u98df\u3068\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u3092\u542b\u3080\u8a66\u9a13\u98df\u3092\u540c\u6642\u6442\u53d6\u3057\u305f\u969b\u306b\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u691c\u8a3c\u3092\u5b9f\u65bd\u3057\u3066\u3044\u305f\u3002\u63a1\u7528\u6587\u732e\u306b\u306f\u3001\u4e09\u83f1\u5546\u4e8b\u30e9\u30a4\u30d5\u30b5\u30a4\u30a8\u30f3\u30b9\u682a\u5f0f\u4f1a\u793e\u306e\u793e\u54e1\u304c\u8457\u8005\u3068\u3057\u3066\u542b\u307e\u308c\u3066\u3044\u305f\u304c\u3001\u672c\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u306f\u63a1\u7528\u6587\u732e\u306e\u8457\u8005\u3092\u9664\u3044\u305f\u793e\u54e1\u306b\u3088\u308a\u516c\u6b63\u306b\u5b9f\u65bd\u3055\u308c\u305f\u3002
\n\u3010\u4e3b\u306a\u7d50\u679c\u3011
\n\u63a1\u7528\u6587\u732e\u3067\u306f\u3001\u5065\u5e38\u6210\u4eba\u304c\u6cb9\u306e\u591a\u3044\u98df\u4e8b\u3068\u5171\u306b\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u3092598.5mg\u6442\u53d6\u3057\u305f\u3068\u304d\u306b\u30d7\u30e9\u30bb\u30dc\u6442\u53d6\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306a\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u6291\u5236\u3068iAUC\u5024\u306e\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad598.5mg\u6442\u53d6\u306b\u3088\u308b\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u4ee5\u4e0a\u304b\u3089\u3001\u5065\u5e38\u6210\u4eba\u304c\u6cb9\u306e\u591a\u3044\u98df\u4e8b\u3068\u5171\u306b\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u3092598.5mg\u6442\u53d6\u3057\u305f\u3068\u304d\u306b\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u305f\u3002
\n\u3010\u79d1\u5b66\u7684\u6839\u62e0\u306e\u8cea\u3011
\n\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u306f\u300c\u4e2d\uff08-1\uff09\u300d\u3001\u975e\u76f4\u63a5\u6027\u306f\u300c\u4f4e\uff080\uff09\u300d\u3001\u4e0d\u7cbe\u78ba\u306f\u300c\u9ad8\uff08-2\uff09\u300d\u3001\u975e\u4e00\u8cab\u6027\u306f\u300c\u4e2d\uff08-1\uff09\u300d\u3001\u305d\u306e\u4ed6\uff08\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306a\u3069\uff09\u306f\u300c\u4e2d\/\u7591\u3044\uff08-1\uff09\u300d\u3068\u306a\u308a\u3001\u5404\u9805\u76ee\u306e\u7dcf\u548c\u304c-5\u3068\u306a\u308a\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u7dcf\u4f53\u306e\u78ba\u5b9f\u6027\u3092\u300c\u4e2d\uff08B\uff09\u300d\u3068\u8a55\u4fa1\u3057\u305f\u3002\u9650\u754c\u3068\u3057\u3066\u3001\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u3084\u4e0d\u7cbe\u78ba\u3001\u975e\u4e00\u8cab\u6027\u3001\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u304c\u5426\u5b9a\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u6319\u3052\u3089\u308c\u308b\u304c\u3001\u5f97\u3089\u308c\u305f\u7d50\u679c\u304b\u3089\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad598.5mg\u306e\u6442\u53d6\u306f\u5065\u5e38\u6210\u4eba\u306e\u98df\u5f8c\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u6291\u5236\u306b\u6709\u52b9\u3067\u3042\u308b\u3068\u5224\u65ad\u3057\u305f\u3002\u307e\u305f\u3001\u63a1\u7528\u6587\u732e\u304c1\u5831\u3068\u5c11\u306a\u3044\u3053\u3068\u304b\u3089\u3001\u4eca\u5f8c\u3001\u8cea\u306e\u9ad8\u3044\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u5341\u5206\u306a\u88ab\u9a13\u8005\u6570\u3067\u5b9f\u65bd\u3057\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u84c4\u7a4d\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3068\u3055\u308c\u308b\u3002\u5c06\u6765\u7684\u306a\u7814\u7a76\u5831\u544a\u306b\u3088\u3063\u3066\u306f\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u306e\u7d50\u679c\u304c\u5909\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u7d99\u7d9a\u7684\u306a\u8abf\u67fb\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/p>\n

\u3010\u6a19\u984c\u3011
\n\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u306b\u3088\u308b\u5065\u5e38\u6210\u4eba\u306b\u5bfe\u3059\u308b\u98df\u5f8c\u8840\u7cd6\u5024\u4e0a\u6607\u6291\u5236\u4f5c\u7528\u306e\u6a5f\u80fd\u6027\u306b\u95a2\u3059\u308b\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\uff08\u66f4\u65b0\u7248\uff09
\n\u3010\u76ee\u7684\u3011
\n\u5065\u5e38\u6210\u4eba\uff08P\uff09\u304c\u30c8\u30eb\u30e9\u9175\u6bcd\u7531\u6765\u98df\u7269\u7e4a\u7dad\u3092\u7d4c\u53e3\u6442\u53d6\uff08I\uff09\u3059\u308b\u3053\u3068\u3067\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\uff08C\uff09\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u4e0a\u6607\u3092\u6291\u5236\uff08O\uff09\u3067\u304d\u308b\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002
\n\u3010\u80cc\u666f\u3011
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